台灣大學89學年度第二學期		開課系所：化學系、所 (選修)
課程名稱：生物無機化學 (2學分)		課程編號：223 U0840
授課對象：化學所碩、博士生選修          化學系大三、大四生選修		授課老師：鄭建中教授

2001 Spring-Semester Courses

Bioinorganic Chemistry

Metals in Nucleic Acids and Proteins

By Chien-Chung Cheng (鄭建中)

Institute of Chemistry, Academia Sinica (中央研究院化學所)

Phone: (02)27898578  FAX: (02)27831237  Email: cccheng@chem.sinica.edu.tw

Importance of Metals in Biological System

Electronic and Coordination Structure of Metal Ions in Biology;

Principle of Coordination Chemistry related to Bioinorganic Chemistry, included pKa values, redox potential, chelate Effect, Ligand effect, substitution. 

Introduction of basic components and structural analysis of DNA/RNA;

Basic Concept of DNA/RNA Synthesis in vitro and in vivo (transcription and translation);

Binding with Inorganic Molecules;

Chemical- and Bio-analytic Methods in Nucleic Acids;

Inorganic Complexes as Nucleic Acids Structural Probes;

Medicinal Inorganic Compounds in Chemotherapeutic Agents

Introduction of the properties of peptides and protein (alpha and beta)

Metal-ion Influence in Protein Structures

Chemical- and Bio-Analytic Methods in protein;

Metals uptake, transportation, and regulation

Electron-transfer proteins

Small Molecules-Activation and -Transfer Reactions

Hydrolytic Enzymes

General References

1. S. J. Lippard and J. M. Berg “Principles of Bioinorganic Chemistry”, 1994, University Science Books.

 2. G. M. Blackburn and M. J. Gait “Nucleic Acids in Chemistry and Biology”, 1996, Oxford University Press. 

3. C. Branden and J. Tooze “Introduction to Protein Structure”,1991, Garland Publishing, Inc.. 

4. M.J. Clarke and P. J. Sadler “Metallopharmaceuticals I”, 1999, Springer-Verlag. 

5. Bertini, Gray, Lippard, and Valentine “Bioinorganic Chemistry”, 1994, University Science Books.

6. A. Fersht “Structure and Mechanism in Protein Science - A Guide to Enzyme Catalysis and Protein-Folding” 1999.