Fang, Jim-Min
 Professor, Organic and Bioorganic Chemistry
Room 301B

Tel: (02)23637812

Fax:(02)23636359 (Chemistry Department)

Jmfang@ ntu.edu.tw

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J.-M. Fang's Group Homepage

Born 1952.  B.S., 1974, National Taiwan Univ.; Ph.D., 1980, Yale Univ.; Postdoctoral Research, 1981, Columbia Univ.; 1982, Suntory Institute for Bioorganic Research; Associate Professor, 1982; Professor, 1986-present; Chairman, 1993-96, Dept. of Chemistry, National Taiwan Univ.; Visiting Scholar, 1988, Univ. Louis Pasteur; 1993, Scripps Research Institute; 1996, Univ. Oxford; 2002, Chuo University; National Science Council Invited Principal Investigator, 1997-present; Foundation Chair Professor, 1999-2004.

An ultrasensitive fluorescent probe for glucoside shows a 60 nm shift on complexation.

Research Interests

1.          New Synthetic Methods

2.          Asymmetric Catalysis

3.          Biomolecular Recognition

4.          Medicinal Chemistry

5.          NanoBioScience

Redox of 5-oxoalkanal is realized by the cooperative catalysis of samarium ion and mercaptan to carry on a multistep sequence reminiscent to cellular conversion of puruvate to acetyl CoA.


Selected Publications

1.            Liao, J.-H.; Chen, C.-T.; Chou, H.-C.; Cheng, C.-C.; Chou, P.-T.; Fang, J.-M.; Slanina, Z.; Chow, T. J. ¡§2,7-Bis-(1H-pyrrol-2-yl)ethynyl-1,8-naphthyridine: An Ultrasensitive Fluorescent Probe for Glucopyranoside. ¡¨Org. Lett. 2002, 4, 3107-3110.

2.            Yang, S.-M.; Shie, J.-J.; Fang, J.-M.; Nandy, S. K.; Chang, H.-Y.; Lu, S.-H.; Wang, G.¡§ Synthesis of Polysubstituted Benzothiophenes and Sulfur-Containing Polycyclic Aromatic Compounds via Samarium Diiodide Promoted Three-Component Coupling Reactions of Thiophene-2-carboxylate. ¡¨ J. Org. Chem. 2002, 67, 5208-5215.

3.            Liao, J.-H.; Chen, C.-T.; Fang, J.-M.¡§A Novel Phosphate Chemosensor Utilizing Anion Induced Fluorescence Change. ¡¨Org. Lett. 2002, 4, 561-564.

4.            Hsu, J.-L.; Fang, J.-M.¡§ Stereoselective Synthesis of ƒÔ-Lactones from 5-Oxoalkanals via One-Pot Sequential Acetalization, Tishchenko Reaction and Lactonization by Cooperative Catalysis of Samarium Ion and Mercaptan. ¡¨ J. Org. Chem. 2001, 66, 8573-8584.

5.            Talukdar, S.; Chen, R.-J.; Chen, C.-T.; Lo, L.-C.; Fang, J.-M.¡§Polymer-Supported Benzotriazoles as Catalysts in the Synthesis of Tetrahydroquinolines by Condensation of Aldehydes with Aromatic Amines. ¡¨J. Comb. Chem. 2001, 3, 341-345.

 


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