LIN, Chun-Hung
Professor (joint appointment)
Room 802, Institute of Biologi
Fax: +886-2-2651-4705
Research Interest
- Carbohydrate-related enzymes, in particular in association with diseases
- Protein cysteine modification linked to redox regulation
Career and Service Experiences
- B.S., 1990, National Taiwan University.
- Ph.D., 1995, Scripps Research Institute.
- Research Fellow, 1997, Harvard Medical School.
- Assistant Research Fellow, 1997-2002, the Institute of Biological Chemistry, Academia Sinica.
- Associate Research Fellow, 2002-2007, the Institute of Biological Chemistry, Academia Sinica.
- Research Fellow, 2007-present, the Institute of Biological Chemistry, Academia Sinica.
- Adjunt Professor, 2015-present, National Taiwan University.
Honors and Awards
- Glaxo Fellowship, 1993-1994
- Heritage Prize and Fellowship of the Lee Foundation,
1998-1999
- A co-recipient of the 2000 Presidential Green Chemistry Challenge Award honoring C.-H. Wong
- Mentor Recognition Award 2005, University of California at San Diego (UCSD)
- Excellent Young Scientist (from the Chemical Society at Taipei), 2006
- The Distinguished Lectureship Award of the Asian International Symposium by the Chemical Society of Japan, 2007
- Selected as one of The 2008 Top 10 Rising Stars in Taiwan by the Central News Agency of Taiwan
- Young Affiliate of TWAS (The Academy of Sciences for the Developing World) ,2008-2012
- The 2009 Lectureship Award to visit Japan supported by Asian Core Program
- The 2010 Young Scholar Award of Tien-De Li Biomedical Foundation
- The 2010 Yong Investigator Award of Academia Sinica
- Investigator Award of Academia Sinica, 2011
- The 2011 Lectureship Award to visit Korea supported by Asian Core Program
- 2014 Outstanding Research Award of National Science Council
Selected Publications
- Yu-Nong Lin, Daniel Stein, Sheng-Wei Lin, Sue-Ming Chang, Ting-Chien Lin, Yu-Ruei Chuang, Jacquelyn Gervay-Hague, Hisashi Narimatsu, Chun-Hung Lin* “Chemoenzymatic Synthesis of GDP-l-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors.” Advanced Synthesis & Catalysis, 2012.
- C.-M. Chong, S. Gao, B.-Y. Chiang, W.-H. Hsu, T.-C. Lin, T.-C. Chen, C.-H. Lin* “ An Acyloxymethyl Ketone-based Probe to Monitor the Activity of Glutathionylspermidine Amidase in Escherichia coli.” ChemBioChem, 2011.
- H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, C.-H Lin, A.H.-J.Wang “Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range.” Angewandte Chemie-International Edition, 2010.
- Chiang BY, Chen TC, Pai CH, Chou CC, Chen HH, Ko TP, Hsu WH, Chang CY, Wu WF, Wang AH, Lin CH “Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION.” Journal of Biological Chemistry, 2010.
- Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin “Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells.” Proc. Natl. Acad. Sci. USA, 2009.
- D. B. Stein, Yu Nong. Lin, Chun Hung Lin* “Characterization of Helicobacter pylori α1,2-Fucosyltransferase for Enzymatic Syntehsis of Tumor-Associated Antigens.” Adv. Synth. Catal., 2008.
- H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin “Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.” J Biol Chem, 2007.
- C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin “Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase.” EMBO J, 2006.
- C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong and C. H. Lin “Discovery of Picomolar Slow Tight-Binding Inhibitors of alpha-Fucosidase.” Chemistry & Biology, 2004.
- C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin “Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.”Angewandte Chemie-International Edition, 2003.
Update: 2021-11-19