- Degradation Mechanisms of Oxidized Proteins
- Proteasome Composition and Function
- Cellular Antioxidant Defense
- Neurochemical Changes at Neuronal Synapses in Alzheimer's Disease
Our central research focus is protein damage and quality control, and their roles in aging and neurodegenerative disorders:
- We are developing novel neurochemical approaches to study neuronal synapses from postmortem brain tissues. We want to understand tau misfolding and other proteomic changes within synapses affected by Alzheimer's disease.
- We want to understand how oxidized proteins are degraded in the cell. We are developing chemical probes to capture the interactome of oxidized proteins.
As a proteomics lab, we are also interested in technical development in protein mass spectrometry and proteomics research.
For my scientific hobby, I study the material and acoustical properties of antique Italian violins. I hope to decode the secrets of Stradivari violins through wood chemical analysis, historical research, and acoustic measurement (collaboration with Chi Mei Museum, Taiwan).
Honors and Awards
- Yuan-Tseh Lee Chemistry Fellowship, 1996-2000.
- California Tobacco-Related Disease Research Program Fellowship, 2004-2007.
- Alzheimer's Disease Research Fellowship, American Health Assistance Foundation, 2010-2012.
- Advisory Board Member, The Savart Journal, 2011-present.
- B.S., 2000, National Taiwan University.
- Ph.D., 2009, California Institute of Technology, USA.
- Postdoctoral fellow, 2010-2012, Harvard Medical School and Massachusetts General Hospital, USA.
- Assistant Professor, 2012-present, National Taiwan University.