Welcome to NTU Chemistry Department

Tai, Hwan-Ching
Tai, Hwan-Ching

Associate Professor
Chemical Biology

Room B477, Chemistry Building

Tel: +886-2-3366-8682

Research Interests

  • Degradation Mechanisms of Oxidized Proteins
  • Proteasome Composition and Function
  • Cellular Antioxidant Defense
  • Neurochemical Changes at Neuronal Synapses in Alzheimer's Disease

Our central research focus is protein damage and quality control, and their roles in aging and neurodegenerative disorders:

  1. We are developing novel neurochemical approaches to study neuronal synapses from postmortem brain tissues. We want to understand tau misfolding and other proteomic changes within synapses affected by Alzheimer's disease.
  2. We want to understand how oxidized proteins are degraded in the cell. We are developing chemical probes to capture the interactome of oxidized proteins.

As a proteomics lab, we are also interested in technical development in protein mass spectrometry and proteomics research.

For my scientific hobby, I study the material and acoustical properties of antique Italian violins. I hope to decode the secrets of Stradivari violins through wood chemical analysis, historical research, and acoustic measurement (collaboration with Chi Mei Museum, Taiwan).

Honors and Awards

  • Yuan-Tseh Lee Chemistry Fellowship, 1996-2000.
  • California Tobacco-Related Disease Research Program Fellowship, 2004-2007.
  • Alzheimer's Disease Research Fellowship, American Health Assistance Foundation, 2010-2012.
  • Advisory Board Member, The Savart Journal, 2011-present.


  • B.S., 2000, National Taiwan University.
  • Ph.D., 2009, California Institute of Technology, USA.
  • Postdoctoral fellow, 2010-2012, Harvard Medical School and Massachusetts General Hospital, USA.
  • Assistant Professor, 2012-2017, National Taiwan University.
  • Associate Professor, 2017-present, National Taiwan University.

Research Pictures

Tai, Hwan-Ching

Selected Publication

(A) Chemistry and Biomedical Research

  1. Chen C. C.; Su, W. C.; Huang, B. Y.; Chen, Y. J.; Tai, H.-C.*; Obena, R. P.* “Interaction Modes and Approaches to Glycopeptide and Glycoprotein Enrichment. Analyst 2014, 139, 688–704.
  2. Perez-Nievas, B. G.; Stein, T.; Tai, H.-C.*; Dols-Icardo, O.; Scotton, T. C.; Barroeta-Espar, I. Fernandez-Carballo, L., de Munain. E. L., Perez, J., Serrano-Pozo, A., Frosch, M. P., Lowe, V., Parisi, J. E., Petersen, R. C., Ikonomovic, M. D., Lopez. O. L., Klunk, W., Hyman, B. T., Gomez-Isla, T.* “Dissecting Phenotypic Traits Linked to Human Resilience to Alzheimer's Pathology” Brain 2013, 136, 2510–2526.
  3. Kopeikina, K. J.; Polydoro, M.; Tai, H.-C.*; Yaeger. E.; Carlson, G. A.; Pitstick, R.; Hyman, B. T.; Spires-Jones, T. L.* “Synaptic Alteration in the rTg4510 Mouse Model of Tauopathy” J. Comp. Neurol. 2013, 521, 1334–1353.
  4. Taylor, A. M.*; Wu, J.; Tai, H.-C.*; Schuman, E. M.* “Axonal Translation of β-Catenin Regulates Synaptic Vesicle Dynamics” J. Neuosci. 2013, 33, 5584–5589.
  5. Tai, H.-C.*; Serrano-Pozo, A.; Hashimoto, T.; Frosch, M. P.; Spires-Jones, T. L.; Hyman, B. T.* “The Synaptic Accumulation of Hyperphosphorylated tau Oligomers in Alzheimer Disease is Associated with Dysfunction of the Ubiquitin-Proteasome System” Am. J. Path. 2012, 181, 1426–1435.
  6. Koffie, R. M. ; Hashimoto, T.; Tai, H.-C.*; Serrano- Pozzo, A.; Joyner, D.; Hou, S. ; Kopeikina, K. J.; Frosch, M. P.; Lee, V. M., Holtzman; D. M.; Hyman, B. T. ; Spires-Jones, T. L.*. “Apolipoprotein E4 Effects in Alzheimer's Disease are Mediated by Synaptotoxic Oligomeric Amyloid-β” Brain 2012, 135, 2155–2168.
  7. Tai, H.-C.*; Besche, H., Goldberg, A. L., Schuman, E. M.* “Characterization of the Brain 26S Proteasome and its Interacting Proteins” Front. Mol. Neurosci. 2010, 3, 12.
  8. Tai, H.-C.*; Schuman, E. M.* “Angelman syndrome: Finding the lost” Arc. Cell 2010, 140, 608–610.
  9. Tai, H.-C.*; Schuman,E. M.* “Ubiquitin, the Proteasome and Protein Degradation in Neuronal Function and Dysfunction” Nat. Rev. Neurosci. 2008, 9, 826–838.
  10. Tai, H.-C.; Schuman, E. M.* “MicroRNA: MicroRNAs Reach out into Dendrites” Curr. Biol. 2006, 16, R121–123.
  11. Lin, W.-Y.; Murugesh, M. G.; Sudhakar, S.; Yang, H.-C.; Tai, H.-C.; Chang, C.-S.; Liu, Y.-H.; Wang, Y.; Chen, I-W.; Chen, C.-h.; Luh, T.-Y.* “On the Rigidity of Polynorbornenes with Dipolar Pendant Groups” Chem. Eur. J. 2005, 12, 324–330.
  12. Tai, H.-C.; Khidekel, N.; Ficarro, S. B.; Peters, E. C.; Hsieh-Wilson, L. C.* “Parallel Identification of O-GlcNAc Modified Proteins from Cell Lysates” J. Am. Chem. Soc. 2004, 126, 10500–10501.

(B) Violin Research

  1. Tai, H.-C. “Stradivari's Varnish: A Review of Scientific Findings, Part 1.” Journal of the Violin Society of America: VSA Papers, 2007, 21, 119–144.
  2. Tai, H.-C. “Stradivari's Varnish: A Review of Scientific Findings, Part 2.” Journal of the Violin Society of America: VSA Papers, 2009, 22, 60–90.
  3. Tai, H.-C.*; Chung, D.-T. “Stradivari Violins Exhibit Formant Frequencies Resembling Vowels Produced by Females” Savart Journal 2012, 1, online publication.

Department of Chemistry, National Taiwan University
Address: No. 1, Sec. 4, Roosevelt Road, Taipei, 10617 Taiwan(R.O.C.) Phone: +886-2-3366-1138~41 Fax: +886-2-3366-8671
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