Welcome to NTU Chemistry Department

Cheng, Richard P.
Cheng, Richard P.

Professor
Bioorganic, Biophysical and Peptide Chemistry

Room B678, Chemistry Building

Tel: +886-2-3366-9789
Fax: +886-2-3366-8670
rpcheng@ntu.edu.tw


Research Interests

  • Bioorganic Chemistry
  • Non-natural Amino Acid Synthesis
  • Application of Fluoro-amino Acids
  • Protein Electrostatics
  • Effect of Side Chain Lengths

Honors and Awards

  • National Institutes of Health Predoctoral Traineeship, 1993-1997.
  • National Institutes of Health Postdoctoral Fellowship, 1998-2001.
  • NYSTAR James D. Watson Young Investigator Award, 2003-2004.
  • Recruiting Outstanding Young Scholar Award, Foundation for the Advancement of Outstanding Scholarship, 2008-2013.
  • Asian Core Program Lectureship Award, 2010.
  • Outstanding Young Chemist Award, Chinese Chemical Society, 2010.
  • Excellence in Teaching Award, National Taiwan University, 2010.

Career

  • B.S., 1992, National Taiwan University.
  • Ph. D., 1998, California Institute of Technology.
  • Postdoc, 1998-2002, University of Pennsylvania School of Medicine, DuPont Central Research and Development.
  • Jere Solo Assistant Professor, 2002-2008, The State University of New York at Buffalo.
  • Associate Professor, 2008-2015, National Taiwan University.
  • Professor, 2015-present, National Taiwan University.

Research Pictures

Cheng, Richard P.

Selected Publication

  1. Liu, M.-C.; Chen, C.-Y.; Chiang, C.-H.; Wang, W.-M.; Cheng, R. P.*, Effect of Lysine Methylation and Acetylation on the RNA Recognition and Cellular Uptake of Tat-Derived Peptides. Bioorg. Med. Chem. 2016, in press (DOI: 10.1016/j.bmc.2016.08.015).
  2. Chen, Y.-T.; Chao, W.-C.; Kuo, H.-T.; Shen, J.-Y.; Chen, I.-H.; Yang, H.-C.; Wang, J.-S.; Lu, J.-F.; Cheng, R. P.*; Chou, P.-T.*, Probing the Polarity and Water Environment at the Protein-Peptide Binding Interface Using Tryptophan Analogues. Biochem. Biophys. Rep. 2016, 7, 113–118.
  3. Wu, C.-H.; Chen, Y.-P.; Liu, S.-L.; Chien, F.-C.; Mou, C.-Y.; Cheng, R. P.*, Attenuating HIV Tat/TAR-Mediated Protein Expression by Exploring the Side Chain Length of Positively Charged Residues. Org. Biomol. Chem. 2015, 13, 11096–11104.
  4. Koubek, J.; Chen, Y.-R.; Cheng, R. P.; Huang, J. J. T.*, Nonorthogonal tRNAcysAmber for Protein and Nascent Chain Labeling. RNA 2015, 21, 1672–1682.
  5. Kuo, H.-T.; Liu, S.-L.; Chiu, W.-C.; Fang, C.-J.; Chang, H.-C.; Wang, W.-R.; Yang, P.-A.; Li, J.-H.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.*, EEffect of Charged Amino Acid Side Chain Length on Lateral Cross-Strand Interactions between Carboxylate- and Guanidinium-Containing Residues in a β-Hairpin. Amino Acids 2015, 47, 885–898.
  6. Li, J.-H.; Chiu, W.-C.; Yao, Y.-C.; Cheng, R. P.*, Effect of Arginine Methylation on the RNA Recognition and Cellular Uptake of Tat-Derived Peptides. Bioorg. Med. Chem. 2015, 23, 2281–2286.
  7. Kuo, H.-T.; Yang, P.-A.; Wang, W.-R.; Hsu, H.-C.; Wu, C.-H.; Ting, Y.-T.; Weng, M.-H.; Kuo, L.-H.; Cheng, R. P.*, Effect of Side Chain Length on Intrahelical Interactions between Carboxylate- and Guanidinium-Containing Amino Acids. Amino Acids 2014, 46, 1867–1883.
  8. Wu, C.-H.; Weng, M.-H.; Chang, H.-C.; Li, J.-H.; Cheng, R. P.*, Effect of Each Guanidinium Group on the RNA Recognition and Cellular Uptake of Tat-Derived Peptides. Bioorg. Med. Chem. 2014, 22, 3016–3020.
  9. Kuo, H.-T.; Fang, C.-J.; Tsai, H.-Y.; Yang, M.-F.; Chang, H.-C.; Liu, S.-L.; Kuo, L.-H.; Wang, W.-R.; Yang, P.-A.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.*, Effect of Charged Amino Acid Side Chain Length on Lateral Cross-Strand Interactions between Carboxylate-Containing Residues and Lysine Analogs in a β-Hairpin. Biochemistry 2013, 52, 9212–9222.
  10. Wu, C.-H.; Chen, Y.-P.; Wu, S.-H.; Hung, Y.; Mou, C.-Y.*; Cheng, R. P.*, Enhanced Non-Endocytotic Uptake of Mesoporous Silica Nanoparticles by Shortening the Peptide Transporter Arginine Side Chain. ACS Appl. Mater. Interfaces 2013, 5, 12244–12248.
  11. Kuo, L.-H.; Li, J.-H.; Kuo, H.-T.; Hung, C.-Y.; Tsai, H.-Y.; Chiu, W.-C.; Wu, C.-H.; Wang, W.-R.; Yang, P.-A.; Yao, Y.-C.; Wong, T. W.; Huang, S.-J.; Huang, S.-L.; Cheng, R. P.*, Effect of Charged Amino Acid Side Chain Length at Non-Hydrogen Bonded Strand Positions on β-Hairpin Stability. Biochemistry 2013, 52, 7785–7797.
  12. Koubek, J.; Lin, K. F.; Chen, Y. R.; Cheng, R. P.*; Huang, J. J. T.*, Strong Anion-Exchange Fast Performance Liquid Chromatography as a Versatile Tool for Preparation and Purification of RNA Produced by in vitro Transcription. RNA 2013, 19, 1449–1459.
  13. Wu, C.-H.; Chen, Y.-P.; Mou, C.-Y.; Cheng, R. P.*, Altering the Tat-Derived Peptide Bioactivity Landscape by Changing the Arginine Side Chain Length. Amino Acids 2013, 44, 473–480.
  14. Cheng, R. P.*; Wang, W.-R.; Girinath, P.; Yang, P.-A.; Ahmad, R.; Li, J.-H.; Hart, P.; Kokona, B.; Fairman, R.; Kilpatrick, C.; Argiros, A., Effect of Glutamate Side Chain Length on Intrahelical Glutamate-Lysine Ion Pairing Interactions. Biochemistry 2012, 51, 7517–7172.
  15. Cheng, R. P.*; Weng, Y.-J.; Wang, W.-R.; Koyack, M. J.; Suzuki, Y.; Wu, C.-H.; Yang, P.-A.; Hsu, H.-C.; Kuo, H.-T.; Girinath, P.; Fang, C.-J., Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length. Amino Acids 2012, 43, 195–206.
  16. Cheng, R. P.*; Girinath, P.; Suzuki, Y.; Kuo, H.-T.; Hsu, H.-C.; Wang, W.-R.; Yang, P.-A.; Gullickson, D.; Wu, C.-H.; Koyack, M. J.; Chiu, H.-P.; Weng, Y.-J.; Hart, P.; Kokona, B.; Fairman, R.; Lin, T.-E.; Barrett, O., Positional Effects on Helical Ala-based Peptides. Biochemistry 2010, 49, 9372–9384.
  17. Chiu, H.-P.; Kokona, B.; Fairman, R.; Cheng, R. P.*, Effect of Highly Fluorinated Amino Acids on Protein Stablity at a Solvent-Exposed Position on an Internal Strand of Protein G B1 Domain. J. Am. Chem. Soc. 2009, 131, 13192–13193.
  18. Heimburg-Molinaro, J.; Almogren, A.; Morey, S.; Glinskii, O. V.; Roy, R.; Wilding, G. E.; Cheng, R. P.; Glinsky, V. V.; Ritenhouse-Olson, K.*, Development, Characterization, and Immunotheapeutic Utilization of Peptide Mimics of the Thomsen-Friedenreich Carbohydrate Antigen. Neoplasia 2009, 11, 780–792.
  19. Chiu, H.-P.; Cheng, R. P.*, Chemoenzymatic Synthesis of (S)-Hexafluoroleucine and (S)-Tetrafluoroleucine. Org. Lett. 2007, 9, 5517–5520.
  20. Cheng, R. P.*; Girinath, P.; Ahmad, R., Effect of Lysine Side Chain Length on Intrahelical Glutamate-Lysine Ion Pairing Interactions. Biochemistry 2007, 46, 10528–10537.
  21. Koyack, M. J.; Cheng, R. P.*, Biological Applications. Foldamers: Structure, Properties, and Applications. 2007, 229–265.
  22. Chiu, H.-P.; Suzuki, Y.; Gullickson, D.; Ahmad, R.; Kokona, B.; Fairman, R.; Cheng, R. P.*, Helix Propensity of Highly Fluorinated Amino Acids. J. Am. Chem. Soc. 2006, 15556–15557.
  23. Koyack, M. J.; Cheng, R. P.*, Design and Synthesis of Biologically Active β-Peptides. Methods Mol. Biol. 2006, 340, 95–109.
  24. Cheng, R. P.*, Beyond de novo protein design-de novo design of non-natural folded oligomers. Curr. Opin. Struct. Biol., 2004, 14, 512.

Department of Chemistry, National Taiwan University
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