Publication List (Jim-Min Fang)

  1. Hsu, T.-W.; Fang, -M. Effective assay of bacterial transglycosylation by molecular turn-on sensing and secondary-order scattering effect. Analyst, 2021, 146, 5843–5847.
  2. Chang, -Y.; Huang, K.-Y.; Chao, T.-L.; Kao, H.-C.; Pang, Y.-H.; Lu. L.; Chiu, C.-L.; Huang, H.-C.; Cheng, T.-J. R.; Fang, J.-M.; Yang, P.-C. Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses. Sci. Rep. 2021, 11, 8692.
  3. Sun, P.-P.; Lai, C.-S.; Hung, C.-J.; Dhaiveegan, P.; Tsai, M.-L.; Chiu, C.-L.; Fang, J.-M. Subchronic oral toxicity evaluation of gold nanoparticles in male and female mice. Heliyon 2021, 7, e06577.
  4. Lin, C.-H.; Lin, H.-Y.; Fang, J.-M.; Chen, C.-C. A dual inhibitor targeting HMG-CoA reductase and histone deacetylase mitigates neurite degeneration in LRRK2-G2019S parkinsonism. Aging 2020, 12, 25581–25598.
  5. Hsu, T.-W.; Hsu, H.-C.; Chan, H.-Y.; Fang, J.-M. A terpyridine zinc complex for selective detection of lipid pyrophosphates: a model system for bacterial O- and N-transglycosylations. J. Org. Chem. 2020, 85, 12747–12753.
  6. Chiu, T.-W.; Peng, C.-J.; Chen, M.-C.; Hsu, M.-H.; Liang, Y.-H.; Chiu, C.-H.; Fang, J.-M.; Lee, Y. C. Constructing conjugate vaccine against Salmonella Typhimurium using lipid-A free lipopolysaccharide. J. Biomed. Sci. 2020, 27, 89.
  7. Hung, W.-T.; Chen, Y.-T.; Chen, C.-H.; Lee, Y. C.; Fang, J.-M.; Yang, W.-B. Flow chemistry system for carbohydrate analysis by rapid labeling of saccharides after glycan hydrolysis. SLAS Technol. 2020, 25, 356–366.
  8. Woodring, J. L.; Lu, S.-H.; Krasnova, L.; Wang, S.-C.; Chen, J.-B.; Chou, C.-C.; Huang, Y.-C.; Cheng, T.-J. R.; Wu, Y.-T.; Chen, Y.-H.; Fang, J.-M.; Tsai, M.-D.; Wong, C. H. Disrupting the conserved salt bridge in the trimerization of influenza A nucleoprotein. J. Med. Chem. 2020, 63, 205–215.
  9. Shie, J.-J.; Fang, J.-M. J. Biomed. Sci. 2019, 26, 1–20. Development of effective anti-influenza drugs: congeners and conjugates – a review
  10. Huang, C.-Y.; Chen, Y.-C.; Wu-Hsieh, B. A.; Fang, J.-M.; Chang, Z.-F. J. Biol. Chem. 2019, 294, 10686-10697. The Ca-loop in thymidylate kinase is critical for growth and contributes to pyrimidine drug sensitivity of Candida albicans
  11. Huang, M.-R.; Hsu, Y.-L.; Lin, T.-C.; Cheng, T.-J.; Li, L.-W.; Tseng, Y.-W.; Chou, Y.-S.; Liu, J.-H.; Pan, S.-H.; Fang, J.-M.; Wong, C.-H. Eur. J. Med. Chem. 2019, 181, 11151. Structure-guided development of purine amide, hydroxamate, and amidoxime for the inhibition of non-small cell lung cancer
  12. Chen, C.-L.; Chiu, T.-W.; Chen, Y.-W.; Fang, J.-M. Tetrahedron. 2019, 75, 4458–4470. Substituent and solvent effects in the 1,3-dipolar cycloadditions forsynthesis of anti-influenza agent peramivir and its analog
  13. Lee, W.-L.; Hsu, T.-W.; Hung, W.-C.; Fang, J.-M. Dalton Trans. 2019, 48, 8026–8029. A copper(II)–dipicolylamine–coumarin sensor for maltosyltransferase assay
  14. Hong, B.-T.; Cheng, Y.-S. E.; Cheng, T.-J.; Fang, J.-M. Eur. J. Med. Chem. 2019, 163, 710–721. Boronate, Trifluoroborate, Sulfone, Sulfinate and Sulfonate Congeners of Oseltamivir Carboxylic Acid: Synthesis and Anti-influenza Activity
  15. Weng, C.H.; Chen, L.-Y.; Lin, Y.-C.; Shih, J.-Y.; Lin, Y.-C.; Tseng, R.-Y; Chiu, A.-C.; Yeh, Y.-H.; Liu, C.; Lin, Y.-T.; Fang, J.-M.; Chen, C.-C. Oncogene. 2019, 38, 455–468. Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI
  16. Tu, L.-H.; Tseng, N.-H.; Tsai, Y.-R.; Lin, T.-W.; Lo, Y.-W.; Charng, J.-L.; Hsu, H.-T.; Chen, Y.-S.; Chen, R.-J.; Wu, Y.-T.; Chan, Y.-T.; Chen, C.-S.; Fang, J.-M.; Chen, Y.-R. Eur. J. Med. Chem. 2018, 158, 393–404. Rationally Designed Divalent Caffeic Amides Inhibit Amyloid-β Fibrillization, Induce Fibril Dissociation, and Ameliorate Cytotoxicity
  17. Hsu, P.-H.; Chiu, D.-C.; Wu, K.-L.; Lee, P.-S.; Jan, J.-T.; Cheng, Y.-S. E.; Tsai, K.-C.; Cheng, T.-J.; Fang, J.-M.* Eur. J. Med. Chem. 2018, 154, 314–323. Acylguanidine Derivatives of Zanamivir and Oseltamivir: Potential Orally Available Prodrugs against Influenza Viruses.
  18. Lee, C.-C.; Chang, C.-P.; Lin, C.-J.; Lai, H.-L.; Kao, Y.-H.; Cheng, S.-J.; Chen, H.-M.; Liao, Y.-P.; Faivre, E.; Buée, L.; Blum, D.; Fang, J.-M.; Chern, Y. Mol. Neurobiol. 2018, 1–17. Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease.
  19. Yu, J.-Y.; Cheng, H.-J.; Wu, H.-R.; Wu, W.-S.; Lu, J.-W.; Cheng, T.-J.; Wu, Y.-T.; Fang, J.-M.* Structure-Based Design of Bacterial Transglycosylase Inhibitors Incorporating Biphenyl, Amine Linker and 2-Alkoxy-3-phosphorylpropanoate Moieties. Eur. J. Med. Chem. 2018, 150, 729–741.
  20. Peng, C.-J.; Chen, H.-L.; Chiu, C.-H.; Fang, J.-M.* ChemBioChem 2018, 19, 805–814. Site-Selective Functionalization of Flagellin by Steric Self-Protection: A Strategy to Facilitate Flagellin as a Self-Adjuvanting Carrier in Conjugate Vaccine. (very important paper selected for issue cover)
  21. Wang, P.-C.; Chiu, D.-C.; Jan, J.-T.; Huang, W.-I; Tseng, Y.-C.; Li, T.-T.; Cheng, T.-J.; Tsai, K.-C.; Fang, J.-M.* Eur. J. Med. Chem. 2018, 145, 224−234. Peramivir Conjugates as Orally Available Agents against Influenza H275Y Mutant.
  22. Chiu, D.-C.; Lin, T.-C.; Huang, W.-I; Cheng, T.-J.;Tsai, K.-C.; Fang, J.-M.* Org. Biomol. Chem. 2017, 15, 9910−9922. Peramivir Analogues Bearing Hydrophilic Side Chains Exhibit Higher Activities against H275Y Mutant than Wild-type Influenza Virus.
  23. Chen, Y.-T.; Hung, W.-T.; Wang, S.-H.; Fang, J.-M.;* Yang, W.-B.* Func. Food Health Dis. 2017; 7, 494−510. Quantitative Analysis of Sugar Ingredients in Beverages and Food Crops by an Effective Method Combining Naphthimidazole Derivatization and 1H-NMR Spectrometry.
  24. Shie, J.-J.;* Liu, Y.-C.; Hsiao, J.-C.; Fang, J.-M.; Wong, C.-H.* Chem. Commun. 2017, 53, 1490−1493. A Cell-Permeable and Triazole-Forming Fluorescence Probe for Glycoconjugate Imaging in Live Cells.
  25. Chen, Y.-H.; Hsu, H.-Y.; Yeh, M.-T.; Chen, C.-C.; Huang, C.-Y.; Chung, Y.-H.;  Chang, Z.-F.; Kuo, W.-C.; Chan, N.-L.; Weng, J.-H.; Chung, B.-c.; Chen, Y.-J.; Jian, C.-B.; Shen, C.-C.; Tai, H.-C.; Sheu, S.-Y.;* Fang, J.-M.* J. Med. Chem. 2016, 59, 9906–9918. Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-induced Degradation.
  26. Chen, Y.-H.; Hsu, H.-Y.; Yeh, M.-T.; Chen, C.-C.; Huang, C.-Y.; Chung, Y.-H.;  Chang, Z.-F.; Kuo, W.-C.; Chan, N.-L.; Weng, J.-H.; Chung, B.-c.; Chen, Y.-J.; Jian, C.-B.; Shen, C.-C.; Tai, H.-C.; Sheu, S.-Y.;* Fang, J.-M.* Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-induced Degradation. J. Med. Chem. 2016, 59, 9906–9918.
  27. Kuo, T.-C.; Li, L.-W.; Pan, S.-H.;* Fang, J.-M.;* Liu, J.-H.; Cheng, T.-J.; Wang, C.-J.; Hung, P.-F.; Chen, H.-Y.; Hong, T.-M.; Hsu, Y.-L.; Wong, C.-H.; Yang, P.-C. J. Med. Chem. 2016, 59, 8521–8534. Purine-type Compounds Induce Microtubule Fragmentation and Lung Cancer Cell Death through Interaction with Katanin.
  28. Wei, T.-T.; Lin, Y.-T.; Tseng, R.-Y.; Shun, C.-T.; Lin, Y.-C.; Wu, M.-S.; Fang, J.-M.; Chen, C.-C. Clin. Cancer Res. 2016, 22, 4158–4169. Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor.
  29. Lin, L.-Z.; Fang, J.-M.* Org. Lett. 2016, 18, 4400–4403. Total Synthesis of Anti-Influenza Agents Zanamivir and Zanaphosphor via Asymmetric Aza-Henry Reaction.
  30. Chen, S.-H.; Chang, C.-H.; Fang, J.-M.* Tetrahedron Lett. 2016, 57, 4293–4296. Diels–Alder reactions of an elusive 1,3-butadiene bearing 2-carboxy and 4-alkoxy substituents.
  31. Hsu, C.-S.; Fang, J.-M.* Eur. J. Org. Chem. 2016, 3809–3816. Synthesis of (+)-Antroquinonol and Analogues by Using Enantioselective Michael Reactions of Benzoquinone Monoketals.
  32. Wang, P.-C.; Fang, J.-M.;* Tsai, K.-C.; Wang, S.-Y.; Huang, W.-I; Tseng, Y.-C.; Cheng, Y.-S. E.; Cheng, T.-J. R.; Wong, C.-H. J. Med. Chem. 2016, 59, 5297–5310. Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors.
  33. Lu, S.-H.; Phang, R.; Fang, J.-M.* Org. Lett. 2016, 18, 1724–1727. Fluorescent Sensing of Guanine and Guanosine Monophosphate with Conjugated Receptors Incorporating Aniline and Naphthyridine Moieties.
  34. Ke, Y.-Y.; Tsai, C.-H.; Yu, H.-M.; Jao, Y.-C.; Fang, J.-M.;* Wong, C.-H.* J. Agric. Food Chem. 2015, 63, 9715–9721. Latifolicinin A from a Fermented Soymilk Product and the Structure–Activity Relationship of Synthetic Analogues as Inhibitors of Breast Cancer Cell Growth.
  35. Lin , H.-H.; Lee, H.-W.; Lin, R.-J.; Huang, C.-W.; Liao, Y.-C.; Chen, Y.-T.; Fang, J.-M.; Lee, T.-C.; Yu, A. L.;* Chang, H.-C.* Small 2015, 11, 4394–4402. Tracking and Finding Slow-Proliferating/QuiescentCancer Stem Cells with Fluorescent Nanodiamonds.
  36. Chou, A.-H.; Chen, Y.-L.; Chiu, C.-C.; Yuan, S.-J.; Weng, Y.-H.; Yeh, T.-H.; Lin, Y.-L.; Fang, J.-M.; Wang, H.-L.* Neuropharmacology 2015, 99, 308–317. T1-11 and JMF1907 Ameliorate Polyglutamine-expanded Ataxin-3-induced Neurodegeneration, Transcriptional Dysregulation and Ataxic Symptom in the SCA3 Transgenic Mouse.
  37. Hsu, C.-S.; Chou, H.-H.; Fang, J.-M.* Org. Biomol. Chem. 2015, 13, 5510–5519. A Short Synthesis of (±)-Antroquinonol in an Unusual Scaffold of 4-Hydroxy-2-cyclohexenone.
  38. Lo, Y.-W.; Fang, J.-M.* Tetrahedron 2015, 71, 266–270. A Short Synthetic Pathway via Three-component Coupling Reaction to Tamiphosphor Possessing Anti-influenza Activity.
  39. Liu, Y.-J. Ju, T.-C.; Chen, H.-M.; Jang, Y.-s.; Lee, L.-M.; Lai, H.-L.; Tai, H.-C.; Fang, J.-M.; Lin, Y.-L.; Tu, P.-H.;* Chern, Y.* Human Molec. Gen. 2015, 24, 787–801. Activation of AMP-activated Protein Kinase α1 Mediates Mislocalization of TDP-43 in Amyotrophic Lateral Sclerosis.
  40. Hong, B.-T.; Chen, C.-L.; Fang, J.-M.;* Tsai, K.-C.; Wang, S.-Y.; Huang, W.-I; Cheng, Y.-S. E.; Wong, C.-H. Bioorg. Med. Chem. 2014, 22, 6647–6654.Oseltamivir Hydroxamate and Acyl Sulfonamide Derivatives as Influenza Neuraminidase Inhibitors.
  41. Shie, J.-J.; Liu, Y.-C.; Lee, Y.-M.; Lim, C.; Fang, J.-M.; Wong, C.-H.* J. Am. Chem. Soc. 2014, 136, 9953−9961. An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation.
  42. Chen, C.-L.; Lin, T.-C.; Wang, S.-Y.; Shie, J.-J.; Tsai, K.-C.; Cheng, Y.-S. E.; Jan, J.-T.; Lin, C.-J.;* Fang, J.-M.;* Wong, C.-H.* Eur. J. Med. Chem. 2014, 81, 106–118. Tamiphosphor Monoesters as Effective Anti-influenza Agents.
  43. Cheng, C.-K.; Tsai, C.-H.; Shie, J.-J.; Fang, J.-M.* Future Med. Chem. 2014, 6, 757–774. From Neuraminidase Inhibitors to Conjugates: A Step towards Better Anti-influenza Drugs? (Review article)
  44. Chen, Y.-S.; Yu, H.-M.; Shie, J.-J.; Cheng, T.-J. R.; Wu, C.-Y.;* Fang, J.-M.;* Wong, C.-H.* Bioorg. Med. Chem. 2014, 22, 1766–1772. Chemical Constituents of Plectranthus amboinicus and the Synthetic Analogs Possessing Anti-inflammatory Activity.
  45. Shie, J.-J.; Fang, J.-M.* J. Chin. Chem. Soc. 2014, 61, 127–141. Phosphonate Congeners of Oseltamivir and Zanamivir as Effective Anti-influenza Drugs: Design, Synthesis and Biological Activity. (Invited review article for the 60th Anniversary of the Journal of the Chinese Chemical Society)
  46. Huang, S.-H.; Wu, W.-S.; Huang, L.-Y.; Huang, W.-F.; Fu, W.-C.; Chen, P.-T.; Fang, J.-M.; Cheng, W.-C.;* Cheng, T.-J. R.;* Wong, C.-H.* J. Am. Chem. Soc. 2013, 135, 17078–17089. A New Continuous Fluorometric Assay for Bacterial Transglycosylase Using Förster Resonance Energy Transfer.
  47. Chen, C.-A.; Fang, J.-M.* Org. Biomol. Chem. 2013, 11, 7687–7699. Synthesis of Oseltamivir and Tamiphosphor from N-Acetyl-D-glucosamine.
  48. Ohara, K.; Lin, C.-C.; Yang, P.-J.; Hung, W.-T.; Yang, W.-B.; Cheng, T.-J. R.; Fang, J.-M.;* Wong, C.-H.* J. Org. Chem. 2013, 78, 6390–6411. Synthesis and Bioactivity of b-(1→4)-Linked Oligomannoses and Partially Acetylated Derivatives. (Selected as Feature Article)
  49. Hung, W.-T.; Wang, S.-H.; Chen, C.-H.; Chen, C.-H.; Fang, J.-M.,* Yang, W.-B.* J. Chin. Chem. Soc. 2013, 60, 955–960. Tagging N-Linked Glycan with 2,3-Naphthalenediamine for Mass Spectrometric Analysis. (Award for the best paper of year 2013)
  50. Chen, J.-B.; Chern, T.-R.; Wei, T.-T.; Chen, C.-C.; Lin, J.-H.;* Fang, J.-M.* J. Med. Chem. 2013, 55, 3645–3655. Design and Synthesis of Dual-Action Inhibitors Targeting Histone Deacetylases and 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase for Cancer Treatment.
  51. Wen, H.-Y.; Hsu, P.-H.; Chen, G.-S.; Fang, J.-M.* RSC Advances 2013, 3, 9530–9533. Regenerative Labeling of Saccharides.
  52. Wang, J.-T.; Lin, T.-C.; Chen, Y.-H.; Lin, C.-H.;* Fang, J.-M.* MedChemComm 2013, 4, 783–791. Polyhydroxylated Pyrrolidine and 2-Oxapyrrolizidine as Glycosidase Inhibitors.
  53. Tsai, C.-S.; Yen, H.-Y.; Lin, M.-I; Tsai, T.-I; Wang, S.-Y.; Huang, W.-I; Hsu, T.-L.; Cheng, Y.-S. E.; Fang, J.-M.; Wong, C.-H.* Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 2466–2471. A Cell-Permeable Probe for Identification and Imaging of Sialidases.
  54. Cheng, T.-J. R.; Wang, S.-Y.; Wen, W.-H.; Su, C.-Y.; Lin, M.; Huang, W.-I; Liu, M.-T.; Wu, H.-S.; Wang, N.-S.; Cheng, C.-K.; Chen, C.-L.; Ren, C.-T.; Wu, C.-Y.; Fang, J.-M.;* Cheng, Y.-S. E.;* Wong, C.-H.* Angew. Chem. Int. Ed. 2013, 52, 366–370. Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation.
  55. Cheng, T.-J. R.; Weinheimer, S.; Tarbet, E. B.; Jan, J.-T.; Cheng Y.-S. E.; Shie, J.-J.; Chen, C.-L.; Chen, C.-A.; Hsieh, W.-C.; Huang, P.-W.; Lin, W.-H.; Wang, S.-Y.; Fang, J.-M.;* Hu, O. Y.-P.;* Wong, C.-H.* J. Med. Chem. 2012, 55, 8657–8670. Development of Oseltamivir Phosphonate Congeners as Anti-Influenza Agents.
  56. Liu, K.-C.; Fang, J.-M.;* Jan, J.-T.; Cheng, T.-J. R.; Wang, S.-Y.; Yang, S.-T.; Cheng, Y.-S. E.; Wong, C.-H.* J. Med. Chem. 2012, 55, 8493–8501. Enhanced Anti-influenza Agents Conjugated with Anti-inflammatory Activity.
  57. Kuo, C.-Y.; Wang, S.-H.; Lin, C.; Liao, S. K.-S.; Hung, W.-T.; Fang, J.-M.;* Yang, W.-B.* Molecules 2012, 17, 7387–7400. Application of 2,3-Naphthlenediamine in Labeling Natural Carbohydrates for Capillary Electrophoresis.
  58. Chen, K.-H.; Fang, W.-F.; Chen, Y.-T.; Fang, J.-M.;* Yang, J.-T.* Chem. Eng. J. 2012, 198–199, 33–37. Microflow Synthesis of Saccharide Nucleoside Diphosphate with Cross-coupling Reactions of Monophosphate Components.
  59. Hu, C.-M.; Yeh, M.-T.; Chen, C.-W.; Tsao, N.; Gao, Q.-Z.; Chang, C.-Y.; Lee, M.-H.; Fang, J.-M.; Sheu, S.-Y.; Lin, C.-J.; Tseng, M.-C.; Chen, Y.-J.; Chang, Z.-F.* Cancer Cell 2012, 22, 36–50. Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair.
  60. Chiang, P.-L.; Chou, T.-C.; Wu, T.-H.; Li, C.-C.; Liao, C.-D.; Lin, J.-Y.; Tsai, M.-H.; Tsai, C.-C.; Sun, C.-J.; Wang, C.-H. Fang, J.-M.;* Chen, Y.-T.* Chem. Asian J. 2012, 7, 2073–2079. Nanowire Transistor-based Ultrasensitive Virus Detection with Reversible Surface Functionalization.
  61. Chen, C.-S.;* Yu, Y.-P.; Hsu, C.-H.; Zou, W.; Fang, J.-M.; Wu, S.-H.* Carbohyd. Res. 2012, 354, 87–93. Evaluation of the Regioselective Delactonization of Tri-sialic Acid Lactone by In-Solution Molecular Dynamics Simulation.
  62. Lai, J.; Fang, J.-M.* J. Chin. Chem. Soc. 2012, 59, 426–435. Transformation of D-Serine to Highly Functionalized Cyclohexenecarboxylates in Study of Oseltamivir Synthesis.
  63. Chou, T.-C.; Hsu, W.; Wang, C.-H.; Chen, Y.-J.;* Fang, J.-M.* J. Nanobiotech. 2011, 9, 52. Rapid and Specific Influenza Virus Detection by Functionalized Magnetic Nanoparticles and Mass Spectrometry.
  64. Chen, Y.-T.; Chen, K.-H.; Fang, W.-F.; Tsai, S.-H.; Fang, J.-M.; Yang, J.-T.* Chem. Eng. J. 2011, 174, 421–424. Flash Synthesis of Carbohydrate Derivatives in Chaotic Microreactors.
  65. Shie, J.-J.; Fang, J.-M.;* Lai, P.-T.; Wen, W.-H.; Wang, S.-Y.; Cheng, Y.-S. E.; Tsai, K.-C.; Yang, A.-S.; Wong, C.-H.* J. Am. Chem. Soc. 2011, 133, 17959–17965. A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity.
  66. Liu, K.-C.; Lee, P.-S.; Wang, S.-Y.; Cheng, Y.-S. E.; Fang, J.-M.;* Wong, C.-H. Bioorg. Med. Chem. 2011, 19, 4796–4802. Intramolecular Ion-Pair Prodrugs of Zanamivir and Guanidino-oseltamivir.
  67. Huang, N.-K.; Lin, J.-H.; Lin, J.-T.; Lin, C.-I; Liu, E. M.; Lin, C.-J.; Chen, W.-P.; Shen, Y.-C.; Chen, H.-M.; Chen, J.-B.; Lai, H.-L.; Yang, C.-W.; Chiang, M.-C.; Wu, Y.-S.; Chen, J.-F.; Fang, J.-M.;* Lin, Y.-L.;* Chern, Y.* PLoS One 2011, 6, e20934. A New Drug Design Targeting the Adenosinergic System for Huntington’s Disease.
  68. Chen, J.-B.; Liu, E. M.; Chern, T.-R.; Yang, C.-W.; Lin, C.-I; Huang, N.-K.; Lin, Y.-L.; Chern, Y.; Lin, J.-H.*; Fang, J.-M.* ChemMedChem 2011, 6, 1390–1400. Design and Synthesis of Novel Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.
  69. Lin, T.-C.; Fang, J.-M.* Tetrahedron Lett. 2011, 52, 2232–2234. Diphosphate Formation Using Cyanuric Chloride or Triisopropylbenzenesulfonyl Chloride as the Activating Agents.
  70. Chang, Y.-L.; Liao, S. K.-S.; Chen, Y.-C.; Hung,W.-T.; Yu, H.-M.; Yang, W.-B.*; Fang, J.-M.*; Chen, C.-H.; Lee, Y. C.* J. Mass Spectr. 2011, 46, 247–255. Tagging Saccharides for Signal Enhancement in Mass Spectrometric Analysis.
  71. Shie, J.-J.; Chen, C.-A.; Lin, C.-C.; Ku, A. F.; Cheng, T.-J. R.; Fang, J.-M.*; Wong, C.-H.* Org. Biol. Chem. 2010, 8, 4451–4462. Regioselective Synthesis of Di-C-glycosylflavones Possessing Anti-inflammation Activities.
  72. Wen, W.-H.; Wang, S.-Y.; Tsai, K.-C.; E. Cheng, Y.-S.;, Yang, A.-S.; Fang, J.-M.*; Wong, C.-H. Bioorg. Med. Chem. 2010, 18, 4074–4084. Analogues of Zanamivir with Modified C4-Substituents as the Inhibitors against the Group-1 Neuraminidases of Influenza Viruses.
  73. Liu, C.-Y.; Wang, J.-T.; Shih, H.-W.; Hsu, Y.-F.; Chang, Y.-F.; Chen, C.-W.; Chen, S.-K.; Wang, Y.-C.; Cheng, T.-J. R.; Ma, C.; Wong, C.-H.; Fang, J.-M.*; Cheng, W.-C.* Org. Lett. 2010, 12, 1608–1611. Synthesis and Evaluation of a New Fluorescent Transglycosylase Substrate: Lipid II-based Molecule Possessing a Dansyl-C20 Polyprenyl Moiety.
  74. Chang, C.-C.; Ku, A. F.; Tseng, Y.-Y.; Yang, W.-B.; Fang, J.-M.*; Wong, C.-H.* J. Nat. Prod. 2010, 73, 229–232. 6,8-Di-C-glycosyl Flavonoids from Dendrobium huoshanense.
  75. Lin, C.; Hung, W.-T.; Chen, C.-H.; Fang, J.-M.; Yang, W.-B.* Rapid Commun. Mass Spect. 2010, 24, 85–94. A New Naphthimidazole Derivative for Saccharide Labeling with Enhanced Sensitivity in Mass Spectrometry Detection.
  76. Wen, W.-H.; Lin, M.; Su, C.-Y.; Wang, S.-Y.; Cheng, Y.-S. E.*; Fang, J.-M.*; Wong, C.-H. J. Med. Chem. 2009, 52, 4903–4910. Synergistic Effect of Zanamivir–Porphyrin Conjugates on Inhibition of Neuraminidase and Inactivation of Influenza Virus.
  77. Chen, C.-S.*; Yu, Y.-P.; Lin, B.-C.; Gervay-Hague, J.; Fang, J.-M.; Hsu, C.-P.; Wu, S.-H.* Eur. J. Org. Chem. 2009, 3351–3356. The Observation of C-H···Osp3 Hydrogen Bond in Trisialic Acid Lactone and Its Implication in Cooperative Lactonization.
  78. Cho, C.-C.; Liu, J.-N.; Chien, C.-H.; Shie, J.-J.; Chen, Y.-C.; Fang, J.-M.* J. Org. Chem. 2009, 74, 1549–1556. Direct Amidation of Aldoses and Decarboxylative Amidation of α-Keto Acids: An Efficient Conjugation Method for Unprotected Carbohydrate Molecules.
  79. Chen, K.-H.; Liao, J.-H.; Chan, H.-Y.; Fang, J.-M.* J. Org. Chem. 2009, 74, 895–898. A Fluorescence Sensor for Detection of Geranyl Pyrophosphate by Chemo-Ensemble Method.
  80. Chen, K.-H.; Yang, J.-S.*; Hwang, C.-Y.; Fang, J.-M.* Org. Lett. 2008, 10, 4401–4404. Phospholipid-Induced Aggregation and Anthracene Excimer Formation.
  81. Chang, Y.-F.; Liu, C.-Y.; Guo, C.-W.; Wang, Y.-C.; Fang, J.-M.*; Cheng, W.-C.* J. Org. Chem. 2008, 73, 7197–7203. Solid-Phase Organic Synthesis of Polyisoprenoid Alcohols Using Traceless Sulfone Linker. IF = 4.450; Citation = 9.
  82. Kuo, C.-J.; Shie, J.-J.; Fang, J.-M.*; Yen, G.-R.; Hsu, J. T.-A.; Liu, H.-G.; Tseng, S.-N.; Chang, S.-C.; Lee, C.-Y.; Shih, S.-R.; Liang, P.-H.* Bioorg. Med. Chem. 2008, 16, 7388–7398. Design, Synthesis, and Evaluation of 3C Protease Inhibitors as Anti-Enterovirus 71 Agents.
  83. Shie, J.-J.; Fang, J.-M.*; Wong, C.-H. Angew. Chem. 2008, 120, 5872–5875. Angew. Chem. Int. Ed. 2008, 47, 5788–5791. A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents Tamiflu and Tamiphosphor.
  84. Hsieh, Y. S.-Y.; Chien, C.; Liao, S. K.-S.; Liao, S.-F.; Hung, W.-T.; Yang, W.-B.*; Lin, C.-C.; Cheng, T.-J. R.; Chang, C.-C.; Fang, J.-M.*; Wong, C.-H.* Bioorg. Med. Chem. 2008, 16, 6054–6068. Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense.
  85. Lin, C.; Lai, P.-T.; Liao, S. K.-S.; Hung, W.-T.; Yang, W.-B.*; Fang, J.-M.* J. Org. Chem. 2008, 73, 3848–3853. Using Molecular Iodine in Direct Oxidative Condensation of Aldoses with Diamines: An Improved Synthesis of Aldo-benzimidazoles and Aldo-naphthimidazoles for Carbohydrate Analysis.
  86. Su, C.-Y.; Wang, S.-Y.; Shie, J.-J.; Jeng, K.-S.; Temperton, N. J.; Fang, J.-M.; Wong, C.-H.; Cheng, Y.-S. E.* Antiviral Res. 2008, 79, 199–205. In Vitro Evaluation of Neuraminidase Inhibitors Using the Neuraminidase Dependent Release Assay of Hemagglutinin-Pseudotyped Viruses.
  87. Lee, J.-C.; Shih, S.-R.; Chang, T.-Y.; Tseng, H.-Y.; Shih, Y.-F.; Yen, K.-J.; Chen, W.-C.; Shie, J.-J.; Fang, J.-M.; Liang, P.-H.; Chao, Y.-S.; Hsu, J. T.-A.* Anal. Biochem. 2008, 375, 115–123. A Mammalian Cell-based Reverse Two-Hybrid System for Functional Analysis of 3C Viral Protease of Human Enterovirus 71.
  88. Lee, C.-C.; Kuo, C.-J.; Hsu, M.-F.; Liang, P.-H.; Fang, J.-M.; Shie, J.-J.; Wang, A. H.-J.* FEBS Lett. 2007, 581, 5454–5458. Structural Basis of Mercury- and Zinc-Conjugated Complexes as SARS-CoV 3C-like Protease Inhibitors.
  89. Shie, J.-J.; Fang, J.-M.*; Wang, S.-Y.; Tsai, K.-C.; Cheng, Y.-S. E.; Yang, A.-S.; Hsiao, S.-C.; Su, C.-Y.; Wong, C.-H. J. Am. Chem. Soc. 2007, 129, 11892–11893. Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity.
  90. Yang, M.-C.; Fang, J.-M.*; Kuo, T.-F.; Wang, D.-M.; Huang, Y.-L.; Liu, L.-Y.; Chen, P.-H.; Chang, T.-H. J. Agric. Food Chem. 2007, 55, 8851–8856. Production of Antibodies for Selective Detection of Malachite Green and the Related Triphenylmethane Dyes in Fish and Fishpond Water.
  91. Chen, C.-S.; Wu, S.-H.;* Wu, Y.-Y.; Fang, J.-M.; Wu, T.-H.* Org. Lett. 2007, 9, 2985–2988. Properties of Astaxanthin/Ca2+ Complex Formation in the Deceleration of Cis/Trans Isomerization.
  92. Chen, C.-S.; Yu, Y.-P.; Hsu, C.-H.; Wu, Y.-T.; Zou, W.; Fang, J.-M.; Wu, S.-H.* Eur. J. Org. Chem. 2007, 3648–3654. Conformation of Tri-Sialic Acid Lactone. NMR Spectroscopic Analysis and Molecular Dynamics Simulation.
  93. Huang, N.-K.; Chern, Y.; Fang, J.-M.; Lin, C.-I; Chen, W.-P.; Lin, Y.-L.* J. Nat. Prod. 2007, 70, 571–574. Neuroprotective Principles from Gastrodia elata.
  94. Lin, C.-I; Selvi, S.; Fang, J.-M.*; Chou, P.-T.*; Lai, C.-H.; Cheng, Y.-M. J. Org. Chem. 2007, 72, 3537–3542. Pyreno[2,1-b]pyrrole and Bis(pyreno[2,1-b]pyrrole) as Selective Chemosensors of Fluoride Ion: A Mechanistic Study.
  95. Shie, J.-J.; Fang, J.-M.* J. Org. Chem. 2007, 72, 3141–3144. Microwave Assisted One-Pot Tandem Reactions for the Direct Conversion of Primary Alcohols and Aldehydes to Triazines and Tetrazoles in Aqueous Media.
  96. Yang, S.-M.; Fang, J.-M.* Tetrahedron 2007, 63, 1421–1428. Synthesis of Polycyclic and 4,5-Diacyl Thiophene-2-carboxylates via Intramolecular Friedel–Crafts Alkylations and Unusual Autooxidative Fragmentation of the Derivatives Obtained from the Samarium Diiodide Promoted Coupling Reactions of Thiophene-2-carboxylate with Carbonyl Compounds.
  97. Lu, S.-H.; Selvi, S.; Fang, J.-M.* J. Org. Chem. 2007, 72, 117–122. Ethynyl-Linked (Pyreno)Pyrrole–Naphthyridine and Aniline–Naphthyridine Molecules as Fluorescent Sensors of Guanine via Multiple Hydrogen Bondings.
  98. Liao, J.-H.; Chen, C.-T.; Fang, J.-M.* J. Chin. Chem. Soc. 2006, 53, 1439–1446. Hexaamide Molecule Annexed with Pyrenes for Selective Detection of Phosphate and Pyrophosphate Ions by Ratiometric Fluorescence Changes.
  99. Sun, Y.-Y.; Liao, J.-H.; Fang, J.-M.*; Chou, P.-T.;Shen, C.-H.; Hsu, C.-W.; Chen, L.-C. Org. Lett. 2006, 8, 3713–3716. Fluorescent Organic Nanoparticles of Benzofuran–Naphthyridine Linked Molecules: Formation and Fluorescence Enhancement in Aqueous Media.
  100. Chien, C.-H.; Chang, J.-C.; Yeh, C.-Y.; Lee, G.-H.; Fang, J.-M.; Song, Y.; Peng, S.-M.* Dalton Trans. 2006, 3249-3256. Weak Antiferromagnetic Coupling for Novel Linear Hexanuclear Nickel(II) String Complexes (Ni612+) and Partial Metal–Metal Bonds in Their One-Electron Reduction Products (Ni611+).
  101. Chien, C.-H.; Chang, J.-C.; Yeh, C.-Y.; Lee,G.-H.; Fang, J.-M.; Peng, S.-M.* Dalton Trans. 2006, 2106–2113. Novel Linear Hexanuclear Cobalt String Complexes (Co612+) and One-Electron Reduction Products (Co611+) Supported by Four Bpyany2− Ligands.
  102. Wu, C.-Y.; King, K.-Y.; Kuo, C.-J.; Fang, J.-M.; Wu, Y.-T.; Ho, M.-Y.; Liao, C.-L.; Shie, J.-J.; Liang, P.-H.*; Wong, C.-H.* Chem. Biol. 2006, 13, 261–268. Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease.
  103. Cheng, M.-F.; Yu, H.-M.; Ko, B.-W.; Chang, Y.; Chen, M.-Y.; Ho, T.-I.; Tsai, Y.-M.*; Fang, J.-M.* Org. Biomol. Chem. 2006, 4, 510–518. Practical Synthesis of Potential Endothelin Receptor Antagonists of 1,4-Benzodiazepine-2,5-dione Derivatives Bearing Substituents at the C3-, N1- and N4-Positions.
  104. Chen, R.-J.; Fang, J.-M. J. Chin. Chem. Soc. 2005, 52, 819–826. Chiral Phosphinophenyloxazolines Bearing Alkoxymethyl Substituents: Synthesis and Application in the Palladium Catalyzed Allylic Substitution Reactions.
  105. Huang, J.-H.; Wen, W.-H.; Sun, Y.-Y.; Chou, P.-T.; Fang, J.-M. J. Org. Chem. 2005, 70, 5827–5832. Two-Stage Sensing Property via a Conjugated Donor−Acceptor−Donor Constitution: Application to the Visual Detection of Mercuric Ion.
  106. Shie, J.-J.; Fang, J.-M.;* Kuo, T.-H.; Kuo, C.-J.; Liang, P.-H.;* Huang, H.-J.; Wu, Y.-T.; Jan, J.-T.; Cheng, Y.-S. E.; Wong, C.-H. Bioorg. Med. Chem. 2005, 13, 5240–5252. Inhibition of the Severe Acute Respiratory Syndrome 3CL Protease by Peptidomimetic α,β-Unsaturated Esters.
  107. Shie, J.-J.; Fang, J.-M.;* Kuo, C.-J.; Kuo, T.-H.; Liang, P.-H.;* Huang, H.-J.; Yang, W.-B.; Lin, C.-H.; Chen, J.-L.; Wu, Y.-T.; Wong, C.-H. J. Med. Chem. 2005, 48, 4469–4473. Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease.
  108. Robinson, A.; Fang, J.-M.;* Chou, P.-T.; Liao, K.-W.; Chu, R.-M.; Lee, S. J. ChemBioChem 2005, 6, 1899–1905. Probing Lectin and Sperm with Carbohydrate-Modified Quantum Dots.
  109. Sinchaikul, S.; Pan, F.-M.; Cheng, C.-W.; Wong, C.-H.; Fang, J.-M.; Tseng, M.-J.; Chen, S.-T. Bioorg. Med. Chem. Lett. 2005, 15, 1413–1416. Protein Microarray Using a-Amino Acids as Metal Tags on Chips.
  110. Chang, K.-H.; Liao, J.-H.; Chen, C.-T.; Mehta, B. K.; Chou, P.-T.; Fang, J.-M. J. Org. Chem. 2005, 70, 2026–2032. Stereoselective Recognition of Tripeptides Guided by Encoded Library Screening: Construction of Chiral Macrocyclic Tetraamide Ruthenium Receptor for Peptide Sensing.
  111. Fan, G.-T.; Pan, Y.-s.; Lu, K.-C.; Cheng, Y.-P.; Lin, W.-C.; Lin, S.; Lin, C.-H.; Wong, C.-H.; Fang, J.-M.; Lin, C.-C. Tetrahedron 2005, 61, 1855–1862. Synthesis of a-Galactosyl Ceramide and the Related Glycolipids for Evaluation of Their Activities on Mouse Splenocytes.
  112. Lu, T.-L.; Chen, C.-S.; Yang, F.-L.; Fang, J.-M.; Chen, M.-Y.; Tsay, S.-S.; Li, J.; Zoue, W.; Wu, S.-H. Carbohyd. Res. 2004, 339, 2593–2598. Structure of a Major Glycolipid from Thermus oshimai NTU-063.
  113. Selvi, S.; Pu, S.-C.; Cheng, Y.-M.; Fang, J.-M.; Chou, P.-T. J. Org. Chem. 2004, 69, 6674–6678. Highly Fluorescent Pyreno[2,1-b]pyrroles: First Syntheses, Crystal Structure and Intriguing Photophysical Properties.
  114. Wu, C.-Y.; Jan, J.-T.; Ma, H.-H.; Kuo, C.-J.; Juan, H.-F.; Cheng, Y.-S. E.; Hsu, H.-H.; Huang, H.-C.; Wu, D.; Brik, A.; Liang, F.-S.; Liu, R.-S.; Fang, J.-M.; Chen, S.-T.; Liang, P.-H.; Wong, C.-H.* Proc. Natl. Acad. Sci. USA 2004, 101, 10012–10017. Small Molecules Targeting Severe Acute Respiratory Syndrome Human Coronavirus.
  115. Fang, J.-M.;* Selvi, S.; Liao, J.-H.; Slanina, Z.; Chen, C.-T.;* Chou, P.-T.* J. Am. Chem. Soc. 2004, 126, 3559–3566. Fluorescent and Circular Dichroic Detection of Monosaccharides by Molecular Sensors: Bis[(pyrrolyl)ethynyl]naphthyridine and Bis[(indolyl)ethynyl]naphthyridine.
  116. Yu, H.-M.; Tseng, M.-J.; Fang, J.-M.; Phutrakul, S.; Chen, S.-T. Electrophoresis 2004, 25, 1034–1041. Capillary Electrophoresis Using Immobilized Whole Cells with Over-expressed Endothelin Receptor for Specific Ligand Screening.
  117. Babu, G.; Yu, H.-M.; Yang, S.-M.; Fang, J.-M. Bioorg. Med. Chem. Lett. 2004, 14, 1129–1132. Carbazolothiophene-2-Carboxylic Acid Derivatives as Endothelin Receptor Antagonists.
  118. Shie, J.-J.; Workman, P. S.; Evans, W. J.; Fang, J.-M. Tetrahedron Lett. 2004, 45, 2703–2707. Comparative Study of TmI2, SmI2, and SmI2/HMPA in the Cross Coupling Reactions of 2-Acetylthiophene and Thiophene-2-carboxylate with Carbonyl Compounds.
  119. Cheng, M.-F.; Fang, J.-M. J. Comb. Chem. 2004, 6, 99–104. Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as the Candidates of Endothelin Receptor Antagonism.
  120. Kuo, L.-J.; Liao, J.-H.; Chen, C.-T.;. Huang, C.-H.; Chen, C.-S.; Fang, J.-M. Org. Lett. 2003, 5, 1821–1824. Two-Arm Ferrocene Amide Compounds: Synclinal Conformations for Selective Sensing of Dihydrogen Phosphate Ion.
  121. Lin, C.-C.; Fan, G.-T.; Fang, J.-M. Tetrahedron Lett. 2003, 44, 5281–5283. A Concise Route to Phytosphingosine from Lyxose.
  122. Chen, S.-T.; Fang, J.-M. J. Chin. Chem. Soc. 2003, 50, 927–930. An Improved Method for the Addition Reactions of 1,3-Dichloroacetone with Combined Organolithium-Cerium Trichloride Reagents.
  123. Chen, M.-Y.; Hsu, J.-L.; Shie, J.-J.; Fang, J.-M. J. Chin. Chem. Soc. 2003, 50, 129–133. Direct Oxidative Amidation of Aldoses by Iodine in Ammonia Water.
  124. Shie, J.-J.; Fang, J.-M. J. Org. Chem. 2003, 68, 1158–1160. Direct Conversion of Aldehydes to Amides, Tetrazoles, and Triazines in Aqueous Media by One-Pot Tandem Reactions.
  125. Fan, G.-T.; Lee, C.-C.; Lin, C.-C.; Fang, J.-M. J. Org. Chem. 2002, 67, 7565–7568. Stereoselective Synthesis of Neu5Aca(2→5)Neu5Gc - the Building Block of Oligo/ Poly(→5-OglycolylNeu5Gca2→) Chains in Sea Urchin Egg Cell Surface Glycoprotein.
  126. Liao, J.-H.; Chen, C.-T.; Chou, H.-C.; Cheng, C.-C.; Chou, P.-T.; Fang, J.-M.; Slanina, Z.; Chow, T. J. Org. Lett. 2002, 4, 3107–3110. 2,7-Bis-(1H-pyrrol-2-yl)ethynyl-1,8-naphthyridine: An Ultrasensitive Fluorescent Probe for Glucopyranoside.
  127. Yang, S.-M.; Shie, J.-J.; Fang, J.-M.; Nandy, S. K.; Chang, H.-Y.; Lu, S.-H.; Wang, G. J. Org. Chem. 2002, 67, 5208–5215. Synthesis of Polysubstituted Benzothiophenes and Sulfur-Containing Polycyclic Aromatic Compounds via Samarium Diiodide Promoted Three-Component Coupling Reactions of Thiophene-2-carboxylate.
  128. Ho, T.-I.; Chen, W.-S.; Hsu, C.-W.; Tsai, Y.-M.; Fang, J.-M. Heterocycles 2002, 57, 1501–1506. Synthesis of 1,4-Benzodiazepine-2,5-dione Derivatives.
  129. Shie, J.-J.; Yang, S.-M.; Chen, C.-T.; Fang, J.-M. Org. Lett. 2002, 4, 1099–1102. A Novel Photochromic System of 4,5-Dialkenylthiophenes Constructed by the Samarium Diiodide Promoted Coupling Reactions of Thiophene-2-carboxylate with Aryl Ketones.
  130. Yang, W.-B.; Patil, S. S.; Tsai, C.-H.; Lin, C.-H.; Fang, J.-M. Tetrahedron 2002, 58, 253–259. The Synthesis of L-Gulose and L-Xylose from D-Gluconolactone.
  131. Liao, J.-H.; Chen, C.-T.; Fang, J.-M. Org. Lett. 2002, 4, 561–564. A Novel Phosphate Chemosensor Utilizing Anion Induced Fluorescence Change.
  132. Jong, S.-J.; Fang, J.-M.; Liu, Y.-H.; Wang, Y. J. Chin. Chem. Soc. 2001, 48, 1041–1046. Synthesis of Symmetric and Unsymmetric 1,1'-Dialkenylferrocenes via Samarium Diiodide Promoted Reactions of 1,1'-Diacetylferrocene with Halides.
  133. Hsu J.-L.; Fang, J.-M. J. Org. Chem. 2001, 66, 8573–8584. Stereoselective Synthesis of d-Lactones from 5-Oxoalkanals via One-Pot Sequential Acetalization, Tishchenko Reaction and Lactonization by Cooperative Catalysis of Samarium Ion and Mercaptan.
  134. Talukdar, S.; Chen, R.-J.; Chen, C.-T.; Lo, L.-C.; Fang, J.-M. J. Comb. Chem. 2001, 3, 341–345. Polymer-Supported Benzotriazoles as Catalysts in the Synthesis of Tetrahydroquinolines by Condensation of Aldehydes with Aromatic Amines.
  135. Jong, S.-J.; Chen, C.-T.; Fang, J.-M.; Liu, Y.-H.; Lee, G.-H.; Wang, Y.  Compt. Rend. Acad. Sci. 2001, 4, 487–496. Samarium Diiodide-Promoted Sequential Coupling-Aldol-Reduction Reactions of Ferrocene-Substituted Enones (invited paper for the special issue of radical chemistry).
  136. Jong, S.-J.; Fang, J.-M. J. Org. Chem. 2001, 66, 3533–3537. Synthesis of Ferrocenyl Alkenes, Dienes and Enynes via Samarium Diiodide Promoted Tandem Addition and Dehydration of Ferrocenyl Carbonyls with Halides.
  137. Kuo, C.-W.; Fang, J.-M. Synth. Commun. 2001, 31, 877–892. Synthesis of Xanthenes, Indanes and Tetrahydronaphthalenes via Intramolecular Phenyl-Carbonyl Coupling Reactions.
  138. Chuang, T.-H.; Fang, J.-M. J. Chin. Chem. Soc. 2001, 48, 193–200. A Conformational Study of Cyclohexane-1,3,5-tricarbonitrile Derivatives.
  139. Talukdar, S.; Hsu, J.-L.; Chou, T.-C.; Fang, J.-M. Tetrahedron Lett. 2001, 42, 1103–1105. Direct Transformation of Aldehydes to Nitriles Using Iodine in Ammonia Water.
  140. Talukdar, S.; Fang, J.-M. J. Org. Chem. 2001, 66, 330–333. Reduction and Coupling Reactions of Carbonyl Compounds Using Samarium Metal in Aqueous Media.
  141. Yang, S.-M.; Nandy, S. K.; Selvakumar, A. R.; Fang, J.-M. Org. Lett. 2000, 2, 3719–3721. Distant Functionalization via Incorportion of Thiophene Moieties in Electrophilic Reactions Promoted by Samarium Diiodide.
  142. Sarkar, T. K.; Ghosh, S. K.; Moorthy, J. N.; Fang, J.-M.; Nandy, S. K.; Sathyamurthy, N.; Chakraborty, D. Tetrahedron Lett. 2000, 41, 6909–6913. Photochromism and Photoreactivity of 2,6-Dichloro-4-methyl-3-pyridinecarboxaldehyde in the Solid State.
  143. Jong, S.-J.; Fang, J.-M. Org. Lett. 2000, 2, 1947–1949. Synthesis of [3]Ferrocenophanes via Samarium Diiodide Promoted Reductive Cyclizations of 1,1'-Dicinnamoylferrocenes.
  144. Fang, J.-M.; Chen, M.-Y.; Shiue, J.-S.; Lu, L.; Hsu, J.-L. Terahedron Lett. 2000, 41, 4633–4636. Samarium Diiodide-Mediated Asymmetric Reactions of 8-Phenylmenthyl Esters.
  145. Talukdar, S.; Chen, C.-T.; Fang, J.-M. J. Org. Chem. 2000, 65, 3148–3153. A Stereoselective Route to Polysubstituted Tetrahydroquinolines by Benzotriazole-Promoted Condensation of Aliphatic Aldehydes and Aromatic Amines.
  146. Chuang, T.-H.; Fang, J.-M.; Bolm, C. Synth. Commun. 2000, 30, 1627–1641. Preparation and Catalytic Enantioselective Reactions of C3-Symmetric Tris(oxazoline)s Derived from Kemp’s Triacid.
  147. Hsu, J.-L.; Chen, C.-T.; Fang, J.-M. Org. Lett. 1999, 1, 1989–1991. Cooperative Catalysis of Samarium Diiodide and Mercaptan in a Stereoselective One-Pot Transformation of 5-Oxopentanals into d-Lactones.
  148. Jong, S.-J.; Fang, J.-M.; Lin, C.-H. J. Organomet. Chem. 1999, 590, 42–45. The Reactions of Acylferrocenes with Samarium Diiodide: Reduction, Deoxygenation, Reductive Coupling and Rearrangement.
  149. Yang, S.-J.; Fang, J.-M.; Cheng, Y.-S. J. Chin. Chem. Soc. 1999, 46,811–818. Lignans, Flavones and Phenolic Derivatives from Taxus mairei.
  150. Chen, G.-H.; Hsu, J.-L.; Yang, W.-B.; Fang, J.-M.; Lee, G.-H.; Liu, Y.-H.; Wang, Y. J. Chin. Chem. Soc. 1999, 46,797–810. Preparation of Chiral Phosphorus(V) Reagents and Their Uses with Borane in the Enantioselective Reduction of Ketones.
  151. Cherng, Y.-J.; Fang, J.-M.; Lu, T.-J. J. Org. Chem. 1999, 64, 3207–3212. Pinane-Type Tridentate Reagents for Enantioselective Reactions: Reduction of Ketones and Addition of Diethylzinc to Aldehydes.
  152. Ling, T.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1999, 51, 793–801. Terpenes and Lignans from Leaves of Chamaecyparis formosensis.
  153. Lu, L.; Chang, H.-Y.; Fang, J.-M. J. Org. Chem. 1999, 64, 843–853. Samarium Ion-Promoted Cross-Aldol Reactions and Tandem Aldol/Evans-Tishchenko Reactions.
  154. Yang, S.-M.; Fang, J.-M. J. Org. Chem. 1999, 64, 394–399. Coupling Reactions and Coupling-Alkylations of Thiophenecarbaldehydes Promoted by Samarium Diiodide.
  155. Lin, W.-H.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1999, 50, 653–658. Lignans from Taiwania cryptomerioides.
  156. Bolm, C.; Chuang, T.-H.; Raabe, G.; Fang, J.-M. Synth. Commun. 1999, 29, 43–51. Simple Synthesis of Enantiomerically Pure C2-Symmetric Bisoxazolidines from Amino Alcohols and Formaldehyde.
  157. Yang, S.-J.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1999, 50, 127–130. Abeo-Taxanes from Taxus mairei.
  158. Sarkar, T. K.; Gangopadhyay, P.; Ghorai, B. K.; Nandy, S. K.; Fang, J.-M. Tetrahedron Lett. 1998, 39, 8365–8366. Cyclopentanoid Allylsilanes in Synthesis: A Facile Construction of the 5-8 Fused Carbon Framework of Asteriscanolide.
  159. Yang, S.-J.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1998, 49, 2037–2043. Diterpenes from Taxus mairei.
  160. Lin, S.-C.; Yang, F.-D.; Shiue, J.-S.; Yang, S.-M.; Fang, J.-M. J. Org. Chem. 1998, 63, 2909–2917. Indole-Carbonyl Coupling Reactions Promoted by Samarium Diiodide. Application to the Synthesis of Indole-Fused Compounds.
  161. Lin, W.-H.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1998, 48, 1391–1397. Diterpenoids and Steroids from Taiwania cryptomerioides.
  162. Yang, W.-B.; Fang, J.-M. J. Org. Chem. 1998, 63, 1356–1359. Asymmetric Addition of Trimethylsilyl Cyanide to Benzaldehydes Catalyzed by Samarium(III) Chloride and Chiral Phosphorus(V) Reagents.
  163. Hsieh, Y.-L.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1998, 47, 845–850. Terpenoids and Flavonoids from Pseudotsuga wilsoniana.
  164. Lin, W.-H.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1997, 46, 169–173. Cycloadducts of Terpene Quinones from Taiwania cryptomerioides.
  165. Shiue, J.-S.; Lin, M.-H.; Fang, J.-M. J. Org. Chem. 1997, 62, 4643–4649. Phenyl-Carbonyl Coupling Reactions Promoted by Samarium Diiodide and Hexamethylphosphoramide.
  166. Chen, S.-T.; Fang, J.-M. J. Org. Chem. 1997, 62, 4349–4357. Preparation of Optically Active Tertiary Alcohols by Enzymatic Methods. Application to the Synthesis of Drugs and Natural Products.
  167. Lu, L.; Fang, J.-M.; Lee, G.-H.; Wang, Y. J. Chin. Chem. Soc. 1997, 44, 279–289. One-Pot Formation of Carbonates from the Reactions of Carbonyl Compounds with Samarium Diiodide and Methyl Chloroformate.
  168. Yang, S.-M.; Fang, J.-M. Tetrahedron Lett. 1997, 38, 1589–1592. Reductive Double Electrophilic Reactions of Methyl Thiophenecarboxylate Mediated by Samarium Diiodide and Hexamethylphosphoramide.
  169. Yang, S.-J.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1996, 43, 839–842. Taxanes from Taxus mairei.
  170. Lin, W.-H.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1996, 42, 1657–1663. Diterpenes and Related Cycloadducts from Taiwania cryptomerioides.
  171. Chuang, T.-H.; Fang, J.-M.; Jiaang, W.-T.; Tsai, Y.-M. J. Org. Chem. 1996, 61, 1794–1805. Reductions, Reductive Alkylations and Intramolecular Cyclizations of Acyl Silanes with Samarium Diiodide or Tributyl Hydride.
  172. Chou, W.-C.; Fang, J.-M. J. Org. Chem. 1996, 61, 1473–1477. Use of Ketenedithioacetal as a Latent Carboxylic Acid in the Macrolactonization Applicable to the Synthesis of Dilactonic Pyrrolizidine Alkaloids.
  173. Fang, J.-M.; Chen, Y.-C.; Wang, B.-W.; Cheng, Y.-S. Phytochemistry 1996, 41, 1361–1365. Terpenes from Heartwood of Juniperus chinensis.
  174. Fang, J.-M. Pure Appl. Chem. 1996, 68, 581–584. Synthesis of Natural g-Lactones and a Dilactone Pyrrolizidine Alkaloid via the Reactions of 2-Propenyl-1,3-dithiane.
  175. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1996, 41, 255–261. Diterpenoids from Leaves of Cryptomeria japonica.
  176. Yang, S.-M.; Fang, J.-M. J. Chem. Soc., Perkin Trans. 1 1995, 2669–2671. Samarium Diiodide Promoted Coupling of Thiophenecarbaldehydes.
  177. Hsu, K.-C.; Fang, J.-M.; Cheng, Y.-S. J. Nat. Prod. 1995, 58, 1592–1595. Diterpenes from Pericarps of Chamaecyparis formosensis.
  178. Lin, W.-H.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1995, 40, 871–873. Uncommon Diterpenes with the Skeleton of Six-Five-Six Fused-Rings from Taiwania cryptomerioides.
  179. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1995, 40, 563–566. Flavonoids and Lignans from Leaves of Cryptomeria japonica.
  180. Liao, J.-H.; Cheng, K.-Y.; Fang, J.-M.; Cheng, M.-C.; Wang, Y. J. Chin. Chem. Soc. 1995, 42, 847–860. Oxidation of Alkenes and Sulfides with Transition Metal Catalysts.
  181. Fang, J.-M.; Lin, C.-H.; Bradshaw, C. W.; Wong, C.-H. J. Chem. Soc., Perkin  Trans. 1 1995, 967–978. Enzymes in Organic Synthesis: Oxidoreductions.
  182. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Tetrahedron Lett. 1995, 36, 5367–5370. Synthesis and Structure Determination of Cryptomanhydride, an Uncommon Natural Terpenic Anhydride.
  183. Yang, S.-C.; Fang, J.-M.; Cheng, Y.-S. J. Chin. Chem. Soc. 1995, 42, 573–577. Chemical Constituents from the Root and Aerial Parts of Rosa taiwanensis.
  184. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1995, 39, 603–607. Sesquiterpenes from Leaves of Cryptomeria japonica.
  185. Liao, L.-F.; Tseng, P.-W.; Chou, C.-H.; Chou, W.-C.; Fang, J.-M. Heterocycles 1995, 41, 1967–1977. Synthesis of 2-Propenethials by the Flash Vacuum Pyrolysis of 2-Ethenyl-1,3-dithiolane 1,1-Dioxides.
  186. Cherng, Y.-J.; Fang, J.-M.; Lu, T.-L. Tetrahedron: Asymmetry 1995, 6, 89–92. A New Pinane-Type Tridentate Modifier for Asymmetric Reduction of Ketones with Lithium Aluminum Hydride.
  187. Yang, C.-C.; Fang, J.-M. J. Chem. Soc., Perkin Trans. 1 1995, 879–887. Free-Radical Cyclisations of 2-Amino-2,5-dienenitriles.
  188. Lee, C.-K.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1995, 39, 391–394. Norditerpenes form Juniperus chinensis.
  189. Yang, C.-C.; Sun, P.-J.; Fang, J.-M. J. Chem. Soc., Chem. Commun. 1994, 2628–2630. Palladium-catalysed Regioselective Cyclisation of Unsaturated Bromoanilinoalkenenitriles.
  190. Chang, C.-J.; Fang, J.-M.; Lee, G.-H.; Wang, Y. J. Chem. Soc., Perkin Trans. 1 1994, 3587–3593. Synthesis, Structure and Reactions of Chiral Oxazinones Derived from L-Ephedrine.
  191. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1994, 37, 1109–1114. Labdanes from Cryptomeria japonica.
  192. Chou, W.-C.; Chen, L.; Fang, J.-M.; Wong, C.-H. J. Am. Chem. Soc. 1994, 116, 6191–6194. A New Route to Deoxythiosugars Based on Aldolases.
  193. Fang, J.-M.; Wong, C.-H. Synlett 1994, 393–402. Account, Enzymes in Organic Synthesis: Alteration of Reversible Reactions to Irreversible Processes.
  194. Liang, Y.-L.; Fang, J.-M.; Chow, T.; Ho, T.-I.; Lee, C.-R.; Wang, Y. J. Org. Chem. 1994, 59, 5742–5747. Solution and Solid-State Photochemistry of 2-(N-Methylanilino)-2,4-pentadienenitriles.
  195. Chen, C.-C.; Chen, S.-T.; Chuang, T.-H.; Fang, J.-M. J. Chem. Soc., Perkin Trans. 1 1994, 2217–2221. 2-(N-Methylanilino)-2-phenylthioacetonitrile, A Reagent Tested for Electrophilic, Nucleophilic and Radical Reactions",
  196. Pai, Y.-C.; Fang, J.-M.; Wu, S.-H. J. Org. Chem. 1994, 59, 6018–6025. Resolution of Homoallylic Alcohols Containing Dithioketeneacetal Functionalities. Synthesis of Optically Active g-Lactones by Combination of Chemical and Enzymatic Methods.
  197. Jeng, H.-J.; Fang, J.-M. J. Chin. Chem. Soc. 1994, 41, 803–811. Formation of Pyrrole Derivatives from Heteroatom-Substituted Acetonitriles.
  198. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1994, 35, 1279–1284. Abietanes and Kaurenes from Leaves of Cryptomeria japonica.
  199. Lee, C.-K.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1994, 35, 983–986. Abietanes from Leaves of Juniperus chinensis.
  200. Chou, W.-C.; Yang, S.-A.; Fang, J.-M. J. Chem. Soc., Perkin Trans. 1 1994, 603–609. Reactions of 1,3-Dithiolane 1,3-Dioxides with Nucleophiles.
  201. Lin, C.-D.; Fang, J.-M. J. Chin. Chem. Soc. 1993, 40, 571-579. Preparation and Reactions of 2-Cyanoindole Derivatives.
  202. Kao, S.-F.; Fang, J.-M.; Cheng, Y.-S. J. Chin. Chem. Soc. 1993, 40, 597–600. The Chemical Constituents from the Aerial Part of Rosa transmorrisonensis.
  203. Fang, J.-M.; Sou, Y.-C.; Chiu, Y.-H.; Cheng, Y.-S. Phytochemistry 1993, 34, 1581–1584. Diterpenes from the Bark of Juniperus chinensis.
  204. Shiue J.-S.; Fang, J.-M. J. Chem. Soc., Chem. Commun. 1993, 1277–1278. Samarium Diiodide Promoted Hydroxyalkylations of Indole-3-carbonyls. An Expedient Approach to Pyrrolidino[1,2-a]indoles and Furo[3,4-b]indoles.
  205. Chen, M.-Y.; Fang, J.-M. J. Chem. Soc., Perkin Trans. 1 1993, 1737–1741. Asymmetric Reactions of 8-Phenylmenthyl Pyruvate with Allyltrimethylsilane, Silyl Enol Ethers and Ketene Silyl Acetals.
  206. Yang, C.-C.; Chang, H.-T.; Fang, J.-M. J. Org. Chem. 1993, 58, 3100–3105. Nucleophilic-Type Radical Cyclizations of Indoles:  Conversion of 2-Cyano-3-Substituted Indoles to Spiro-Annelated Indolines and Tetrahydrocarbazolones.
  207. Su, W.-C.; Fang, J.-M.; Cheng, Y.-S. Phytochemistry 1993, 34, 779–782. Hexacarbocyclic Triterpenes from Leaves of Cryptomeria japonica.
  208. Chang, C.-J.; Fang, J.-M.; Liao, L.-F. J. Org. Chem. 1993, 58, 1754–1761. Regio, Stereo- and Enantioselectivity in the Electrophilic Reactions of 2-Amino-4-phenyl-3-butenenitriles.
  209. Fang, J.-M.; Lee, C.-K.; Cheng, Y.-S. Phytochemistry 1993, 33, 1169–1172. Diterpenes from Leaves of Juniperus chinensis.
  210. Shiue, J.-S.; Lin, C.-C.; Fang, J.-M. Tetrahedron Lett. 1993, 34, 335–338. Samarium Diiodide / Hexamethylphosphoramide Promoted Dimerization of Benzaldehydes
  211. Fang, J.-M.; Cheng, Y.-S. J. Chin. Chem. Soc. 1992, 39, 647–654. Account:  Chemical Constituents of Some Endemic Conifers in Taiwan.
  212. Fang, J.-M.; Chen, M.-Y. J. Chin. Chem. Soc. 1992, 39, 431–438. Regiochemistry in Electrophilic Reactions of Propanedithio-Substituted Allylic Anions Influenced by the g-Substituents.
  213. Yang, C.-C.; Fang, J.-M. J. Chem. Soc., Perkin Trans. 1 1992, 3085–3094. Electrophilic Reactions of a-Amino Dienenitriles: Regiochemistry and Stereoselectivity of Trisubstituted Pentadienyl Anions.
  214. Wang, Y.-W.; Fang, J.-M.; Wang, Y.-K.; Wang, M.-H.; Ko, T.-Y.; Cherng, Y.-J. J. Chem. Soc., Perkin Trans. 1 1992, 1209–1213. Addition Reactions of 2-Amino-4-methoxypenta-2,4-dienenitrile with Electrophiles Containing Electron-deficient Multiple Bonds.
  215. Fang, J.-M.; Lee, C.-K.; Cheng, Y.-S. Phytochemistry 1992, 31, 3659–3661. Lignans from Leaves of Juniperus chinensis.
  216. Chen, M.-Y.; Fang, J.-M. J. Org. Chem. 1992, 57, 2937–2941. An Asymmetric Synthesis of Crobarbatic Acid.
  217. Chen, M.-Y.; Fang, J.-M.; Tsai, Y.-M.; Yeh, R.-L. J. Chem. Soc., Chem. Commun. 1991, 1603–1604. Stereogenic Reactions of the a-Carbon Radicals of 8-Phenylmenthyl Esters.
  218. Lee, M.-R.; Hwang, D.-G.; Kao, T.-S.; Chien, C.-C.; Lin, F.-H.; Fang, J.-M. Explosives and Propellants 1991, 7, 1–6. Tandem Mass Spectrometry of HMX and RDX.
  219. Fang, J.-M.; Wang, K.-C.; Cheng, Y.-S. J. Chin. Chem. Soc. 1991, 38, 297–299. The Chemical Constituents from the Aerial Part of Rosa laevigata.
  220. Fang, J.-M.; Wang, K.-C.; Cheng, Y.-S. Phytochemistry 1991, 30, 3383–3387. Steroids and Triterpenoids from Rosa Laevigata.
  221. Fang, J.-M.; Lang, C.-I.; Chen, W.-L.; Cheng, Y.-S. Phytochemistry 1991, 30, 2793–2795. Diterpenoid Acids from the Leaves of Armand Pine.
  222. Fang, J.-M.; Tsai, W.-Y.; Cheng, Y.-S. Phytochemistry 1991, 30, 1333–1336. Serratenes from Pinus Armandii Bark.
  223. Fang, J.-M.; Tsai, W.-Y.; Cheng, Y.-S. J. Chin. Chem. Soc. 1991, 38, 61–64. The Constituents of the Bark of Armand Pine.
  224. Fang, J.-M.; Wang, Y.-W.; Duh, J.-M.; Cheng, M.-C.; Wang, Y. J. Chin. Chem. Soc. 1991, 38, 51–55. A Study of Intramolecular Diels-Alder Reactions of Allylamino Dienenitriles.
  225. Chuang, T.-H.; Yang, C.-C.; Chang, C.-J.; Fang, J.-M. Synlett 1990, 733–734. Base-Catalyzed Autoxidation of a-Aminonitriles. An Efficient Method for Conversion of Aldehydes to Amides and 2-Amino-2-sulfenylacetonitrile to Carbamates.
  226. Fang, J.-M.; Chen, C.-C. J. Chem. Soc. Perkin Trans.1 1990, 3365-3367. 2-(N-Methylanilino)-2-phenylthioacetonitrile: a Useful Reagent for Preparation of Conjugated a-Amino alkenenitriles via Tandem Alkylation and Dehydrosulphenylation",
  227. Fang, J.-M.; Chen, S.-T.; Chen, I.-H. J. Organomet. Chem. 1990, 398, 219–224. Regioselective Addition of Aldimines to the 2-Propenyl-1,3-dithiane Anion.
  228. Fang, J.-M.; Chou, W.-C.; Lee, G.-H.; Peng, S.-M. J. Org. Chem. 1990, 55, 5515–5519. Regio- and Stereochemistry in Electrophilic Reactions of 2-Propenyl-1,3-dithiane 1-Oxide.
  229. Fang, J.-M.; Liu, M.-Y.; Cheng, Y.-S. Phytochemistry 1990, 29, 3048–3049. Lignans from Wood of Calocedrus formosana.
  230. Fang, J.-M.; Chen, M.-Y. Synlett 1990, 285–286. Sulfur-Stabilized Carbanions:  Electrophilic Reactions of an Allylic Anion Containing Propanedithio- and Phenylthio-Substituents.
  231. Tzeng, Y.-L.; Luh, T.-Y.; Fang, J.-M. J. Chem. Soc., Chem. Commun. 1990, 399–400. Nickel-catalysed Alkylative Alkenation of Orthothioesters with Grignard Reagents; a Convenient Procedure for Introduction the Isopropenyl Group.  Synthesis of Substituted 1,3-(Bis-trimethylsilyl)propenes.
  232. Fang, J.-M.; Hsu, K.-C.; Cheng, Y.-S. Phytochemistry 1989, 28, 3553–3555. Lignans from Leaves of Calocedrus formosana.
  233. Fang, J.-M.; Chang, C.-J. J. Chem. Soc., Chem. Commun. 1989,1787–1788. Asymmetric Alkylations of A Chiral a-Amino Alkenenitrile.
  234. Fang, J.-M.; Su, W.-C.; Liang, W.-C.; Cheng, Y.-S. J. Chin. Chem. Soc. 1989, 36, 483–485. A Study of the Constituents of the Wood of Armand Pine.
  235. Chen, M.-Y.; Fang, J.-M. J. Chin. Chem. Soc. 1989, 36, 469–477. Electrophilic Reactions of Dithio-Substituted o-Methoxycinnamyllithium.
  236. Fang, J.-M.; Duh, J.-M.; Chen, C.-T. J. Chem. Res. 1989, S, 275 and M, 2150–2161. Nucleophilic Reactions of 4-Bromo-2-methoxy-4,5-dihydrothiophene 1,1-Dioxide.
  237. Fang, J.-M.; Lin, J.-R.; Duh, J.-M.; Cheng, M.-C.; Wang, Y. J. Chem. Res. 1989, S, 274 and M, 2136–2149. A Study of 2-Methyl-3-phenylsulphinyl-2,3,4,5-tetrahydrothiophene 1,1-Dioxides: N.m.r. Spectra, Crystal Structure, and Dehydrosulphinylations.
  238. Fang, J.-M.; Chen, M.-Y.; Cheng, M.-C.; Lee, G.-H.; Wang, Y.; Peng, S.-M. J. Chem. Res. 1989, S, 272-273 and M, 2101–2135. Toluene-p-sulphonyl Cyanide in Photochemical and Azobisisobutyronitrile-initiated Radical Reactions.
  239. Fang, J.-M.; Chen, S.-A.; Cheng, Y.-S. J. Agric. Food Chem. 1989, 37, 744–746. Quantitative Analysis of the Essential Oil of Cinnamomum osmophloeum Kanehira.
  240. Fang, J.-M.; Yang, C.-C.; Wang, Y.-W. J. Org. Chem. 1989, 54, 481–484. Dihydroazepines from Ring Closure Reaction of a-Allylamino Dienenitriles.
  241. Fang, J.-M.; Yang, C.-C.; Wang, Y.-W. J. Org. Chem. 1989, 54, 477–481. Use of a-Anilino Dienenitriles as Nucleophiles in Cycloadditions.
  242. Fang, J.-M.; Sun, S.-F.; Rei, M.-H. J. Chem. Soc. Perkin Trans. 2 1989, 747–750. Stereochemistry of Nucleophilic Reductions of 2-Methyl-4-t-butylcyclohexanones. Further Support for the Linear Combination of SSC and PSC Stereochemical Model.
  243. Fang, J.-M.; Hsu, K.-C.; Cheng, Y.-S. Phytochemistry 1989, 28, 1173–1175. Terpenoids from Leaves of Calocedrus formosana.
  244. Fang, J.-M.; Chen, M.-Y. Tetrahedron Lett. 1988, 29, 5939–5940. Boron Trifluoride Promoted Reaction of Dithio-Substituted Allylic Anions and Cyclic Ethers.
  245. Fang, J.-M.; Chen, M.-Y.; Yang, W.-J. Tetrahedron Lett. 1988, 29, 5937–5938. Reactions of Dithio-Substituted Cinnamyllithium with Carbonyl Compounds:  A Test of the HSAB Principle.
  246. Foster, K. W.; Saranak, J.; Derguini, F.; Rao, V. J.; Zarrilli, G. R.; Okabe, M.; Fang, J.-M.; Shimizu, N.; Nakanishi, K. J. Am. Chem. Soc. 1988,  110, 6588–6589. Rhodopsin Activation:  A Novel View Suggested by In Vivo Chlamydomonas Experiments.
  247. Fang, J.-M.; Chang, H.-T.; Lin, C.-C. J. Chem. Soc. Chem. Commun. 1988, 1385–1386. Intramolecular Free Radical  Cyclisation of a-Anilino Alkenenitriles.
  248. Fang, J.-M.; Chang, H.-T. J. Chem. Soc. Perkin Trans. 1 1988, 1945–1948. Nucleophilic Reactions of a-Aminoalkenenitriles.
  249. Fang, J.-M.; Su, W.-C.; Cheng, Y.-S. Phytochemistry 1988, 27, 1395–1397. Flavonoids and Stilbenes from Armand Pine.
  250. Fang, J.-M.; Chen, M.-Y. Tetrahedron Lett. 1987, 28, 2853–2856. Free Radical Type Addition of Toluenesulfonyl Cyanide to Unsaturated Hydrocarbons.
  251. Fang, J.-M.; Hong, B.-C. J. Org. Chem. 1987, 52, 3162–3165. Stereoselective Reaction of Dithio-Substituted Crotylmetal with a-Oxy Carbonyl Compounds.
  252. Fang, J.-M.; Chang, C.-F.; Cheng, Y.-S. Phytochemistry 1987, 26, 2559–2561. Flavonoids from Pinus morrisonicol.
  253. Fang, J.-M.; Jan, S.-T.; Cheng, Y.-S. Phytochemistry 1987, 26, 853–854. Terpenoids from Calocedrus formosana.
  254. Fang, J.-M.; Hong, B.-C.; Liao, L.-F. J. Org. Chem. 1987, 52, 855–861. Dichotomous Regiochemistry of Aldehyde and Ketone in the Reaction with Dithio-Substituted Crotyllithium.
  255. Fang, J.-M.; Lai, L.-J.; Cheng, Y.-S. J. Chin. Chem. Soc. 1986, 33, 265–266. The Constituents of the Leaves of Chamaecyparis formosensis Matsum.
  256. Fang, J.-M.; Sheu, C.-M.; Cheng, Y.-S. J. Chin. Chem. Soc. 1986, 33, 245–249. A Study of the Constituents of the Bark of Chamaecyparis formosensis Matsum.
  257. Fang, J.-M.; Jan, S.-T.; Cheng, Y.-S. J. Chem. Res. 1986, S, 350–351. Structural Elucidation of a Natural Secoabietane Dialdehyde. Preparation of a Stable Diterpenoidal Ozonide.
  258. Fang, J.-M.; Liao, L.-F.; Hong, B.-C. J. Org. Chem. 1986, 51, 2828–2829. Regio- and Diastereoselective Reactions of Dithio-Substituted Crotyllithium and Aldehydes.
  259. Fang, J.-M.; Cherng, Y.-J. J. Chem. Res. 1986, S, 180 and M, 1568–1577. A Synthetic Approach to Neplanocin A and Queuosine: Unusual Natural Nucleosides Containing Cyclopentenyl Rings.
  260. Fang, J.-M.; Hong, B.-C. Synth. Commun. 1986, 16, 523–527. A Convergent Synthesis of (±)-Eldanolide Based on Reaction of Aldehyde with Dithio-Substituted Crotyllithium Compound.
  261. Fang, J.-M.; Wu, S.-K.; Cheng, Y.-S. J. Chin. Chem. Soc. 1985, 32, 477–480. A Study of the Constituents of the Bark of Tsuga chinensis Pritz. var. formosana (Hay.)".
  262. Fang, J.-M.; Jan, S.-T.; Cheng, Y.-S. Phytochemistry 1985, 24, 1863–1864. (+)-Calocedrin, A Lignan Dihydroanhydride from Calocedrus formosana.
  263. Fang, J.-M.; Yang, C.-C. J. Chem. Soc. Chem. Commun. 1985, 1356–1357. Cycloadditions of a-Aminonitrile Diene.
  264. Chang, C. H.; Govindjee, R.; Ebrey, T.; Bagley, K. A.; Dollinger, G.; Eisenstein, L.; Marque, J.; Roder, H.; Vittitow, J.; Fang, J.-M.; Nakanishi, K. Biophy. J. 1985, 47, 509–512. Trans/13-Cis Isomerization is Essential for Both the Photocycle and Proton Pumping of Bacteriorhodopsin.
  265. Fang, J.-M.; Wei, K.-M.; Cheng, Y.-S.; Cheng, M.-C.; Wang, Y. Phytochemistry 1985, 24, 1363–1365. (+)-Tsugacetal, A Lignan Acetal from Taiwan Hemlock.
  266. Fang, J.-M.; Wei, K.-M.; Cheng, Y.-S. J. Chin. Chem. Soc. 1985, 32, 75–80. A Study of the Constituents of the Heartwood of Tsuga chinensis Pritz. var. formosana (Hay.).
  267. Fang, J.-M.; Wang, Y.-W. Proc. Natl. Sci. Council 1985, 9, 95–98. Syntheses of (+)-Menthofuran and (+)-Trans-p-Menthenolide via Sequential Oxidations of (-)-Isopulegol.
  268. Fang, J.-M.; Liao, L.-F.; Yang, C.-C. Proc. Natl. Sci. Council 1985, 9, 1–4. Regioselective Reactions of 2-(N-Methylanilino)-2-pentenylnitrile.
  269. Fang, J.-M.; Carriker, J. D.; Nair, V. B.; Nakanishi, K. J. Am. Chem. Soc. 1983, 105, 5162–5164. Evidence for the Necessity of Double Bond (13-ene) Isomerization in the Proton Pumping of Bacteriorhodopsin.
  270. Ziegler, F. E.; Fang, J.-M.; Tam, C. C. J. Am. Chem. Soc. 1982, 104, 7174–7181. Conjugate Addition of Dithianylidene Anions to a,b-Unsaturated Ketones.  An Application to the Total Synthesis of (±)-Aromatin and (±)-Confertin.
  271. Fang, J.-M. J. Org. Chem. 1982, 47, 3464–3470. Michael Reactions in Aprotic Media.  An Effective Method of Construction of a,a,b-Trisubstituted Ketones and Application to the Natural Product Synthesis.
  272. Ziegler F. E.; Fang, J.-M. J. Org. Chem. 1981, 46, 825–827. Regiochemical Control in the Conjugate Addition of Dithianylidene Anions: Total Synthesis of (±)-Aromatin and (±)-Confertin.
  273. Fang, J.-M. Ph. D. Thesis, Yale University, 1981, 195 pages. Sulfur Stabilized Carbanions: The Total Synthesis of (±)-Aromatin and (±)-Confertin.
  274. Cheng, Y.-S.; Tsai, M.-D.; Fang, J.-M.; Hsu, S.-S. Chemistry 1975, 1, 8–11. Dye-Sensitized Photooxidation of a-Terpineol.
  275. Cheng,Y.-S.; Chen, H.-Y.; Fang, J.-M. J. Chin. Chem. Soc. 1975, 22, 341–347. The Neutral Part of the Bark of Pinus luchensis Mayer.

BOOKS:

  1. Fang, J.-M.; Ho, T.-I.; Hsu, S.-P.; Zen, K.-H. Organic Chemistry (in Chinese), Yi-Hsien Pub.: Taipei, 1986, 448 pages.
  2. Fang, J.-M. Contemporary Organic Synthesis (in Chinese), Yi-Hsien Pub.: Taipei, 1986, 314 pages.
  3. Fang, J.-M.; Ho, T.-L.; Chou, T.-S.; Luh, T.-Y.; Kuo, Y.-H.; Tsai, Y.-M. Organic Synthesis (in Chinese), Yi-Hsien Pub.: Taipei, 1993, 601 pages.

PATENTS:

1

Fang, J.-M.; Jong, S.-J. Method of Manufacturing Ferrocenyl-1,3-Butadiene. 方俊民，鍾顯政，「鐵烴基-1,3-丁二烯的合成方法」。

1-1.

US patent US6211392 B1, issued on April 3, 2001.

1-2.

中華民國專利 I220430號, issued on August 21, 2004.

2

Chen, C.-T.; Tang, S.-T.; Lu, L.; Fang, J.-M. 8-Hydroxyjulolidine, Its Analogous Compounds and Preparation Method Thereof. 陳昭岑、唐紹祖、盧凌、方俊民，「8-羥基朱珞力啶及類似化合物的製造方法」。

2-1.

US patent US6433176 B1, issued on August 13, 2002.

2-2.

中華民國專利申請，2001年.

3

林啟萬、李政隆、莊榮輝、林世明、李世光、朱瑞民、王金和、方俊民、莊琮亮「光波導型表面電漿共振感測裝置」，中華民國專利申請，2007年。Optical Waveguide Surface Plasma Resonance Sensor, US patent application, 2008.

4

Chern, Y.; Lin, Y.-L.; Huang, N.-K.; Lin, J.-H.; Fang, J.-M.; Lin, C.-I. Method of Making and Using an Adenosine Analogue. 陳儀莊、林雲蓮、黃乃瑰、林榮信、方俊民、林佳誼 ，「腺苷類似物的製造及使用方法」。

4-1.

US patent US8,129,357 B2, issued on March 6, 2012.

4-2.

中國專利 CN101524361 B, issued on July 4, 2012.

4-3.

中華民國(台灣)專利 I372627, issued on September 21, 2012.

5

Wong, C.-H.; Fang, J.-M.; Shie, J.-J.; Cheng, Y.-S. E.; Jan, J.-T. Synthesis of Oseltamivir Containing Phosphonate Congeners with Anti-influenza Activity. 翁啟惠、方俊民、謝俊結、鄭義循、詹家琮，「具有抗流感活性之含奧司他偉膦酸酯同系物的合成」。

5-1.

US patent US7888337B2, issued on February 15, 2011.

5-2.

中國專利 CN101883569B, issued on August 21, 2013.

5-3.

Australia patent AU2008292859B2, issued on February 20, 2014.

5-4.

Japan patent JP5509080, issued on March 28, 2014.

5-5.

Korea patent KR101535691B1, issued on July 3, 2015.

5-6.

Europe patent EP2190439B1, issued on March 9, 2016, France, UK and Germany.

5-7.

Canada patent CA2697837 C, issued on August 16, 2016.

6

Wong, C.-H.; Cheng, Y.-S.; Yu, H.-M.; Cheng, T.-J.; Wu, C.-Y.; Fang, J.-M. Compositions and Methods for Treating Inflammation and Inflammation-Related Disorders by Plectranthus amboinicus Extracts. US patent US8105636 B2, issued on January 31, 2012.

7

Wong, C.-H.; Yang, W.-B.; Cheng, T.-J.; Hsieh, Y. S.-Y.; Chien, C.; Lin, C.-C.; Wen, H.-Y.; Fang, J.-M. Structure and Bioactivity of the Polysaccharides and Oligomers in Medicinal Plant Dendrobium huoshanense. 翁啟惠、方俊民、楊文彬、鄭婷仁、謝尚逸、簡政、林志謙、溫皓宇，「藥用植物霍山石斛( Dendrobium huoshanense)多醣體及寡聚物之結構及生物活性」。

7-1.

US patent US8354127 B2, issued on January 15, 2013.

7-2.

中華民國專利(台灣) I488636號，issued on June 21, 2015.

8

Lin, Y.-L.; Chern, Y.; Fang, J.-M.; Lin, J.-H.; Huang, N.-K. Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases. 林雲蓮 、陳儀莊 、方俊民、林榮信、黃乃瑰，「結合至腺苷酸Ａ2A受體和腺苷酸轉運子以預防及治療神經退化疾病的雙功能化合物」。

8-1.

中華民國(台灣)專利 I398255 B1, issued on June 11, 2013.

8-2.

中國專利 CN102740849B, issued on November 30, 2016.

8-3.

European patent EP2498774B1, issued on October 11, 2017.

8-4.

Korean patent 10-1830623, issued on February 13, 2018.

8-5.

US patent, allowed on November 28, 2018.

9

Wong, C.-H.; Fang, J.-M.; Cheng, Y.-S. E.; Shie, J.-J. Zanamivir Phosphonate Congeners with Anti-Influenza Activity and Determining Oseltamivir Susceptibility of Influenza Viruses. 翁啟惠、方俊民、鄭義循、謝俊結，「具有抗流感活性的扎那米偉膦酸酯同類物及流感病毒的奧司他偉易感性的測定」。

9-1.

EP 2568976 B1, issued on September 30, 2015.

9-2.

中國專利 CN103068378 B, issued on July 6, 2016.

9-3.

Japan patent JP5947289, issued on July 6, 2016.

9-4.

US patent US9403855B2, issued on August 2, 2016.

9-5.

Australia patent AU2011250970, issued on December 15, 2016.

9-6.

Korean patent KR10-1745386, issued on June 2, 2017.

9-7.

Canada patent CA2835489C, issued on March 6, 2018.

9-8.

Denmark patent DK2975409T3, issued on December 17, 2018.

10

Chang, Z.-F.; Fang, J.-M.; Hu, C.-M.; Yeh, M.-T. Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells. 张智芬、方俊民、胡春美、葉明婷，「標靶人類胸腺核苷酸激酶誘導惡性腫瘤中的DNA修復毒性」。

10-1.

US patent US9278982 B2, issued on March 8, 2016.

10-2.

中國專利 CN103476411 B, issued on March 23, 2016.

11

Chen, C.-C.; Lin, Y.-L.; Fang, J.-M.; Chern, Y.; Lin, C.-C.; Chen, W.-N. Methods and Compositions for Treating Pain. 陳志成、林雲蓮、方俊民、陳儀莊、林家靖、陳威男、林君榮，「治療疼痛之方法及組合物」。

11-1.

中華民國(台灣)專利 I494111號, issued on August 1, 2015.

11-2.

中國專利 ZL201380008966.3，issued on May 24, 2017.

11-3.

European patent allowed on October 31, 2017.

11-4.

US patent allowed on June 27, 2018.

12

Wong, C.-H.; Fang, J.-M.; Liu, K.-C.; Jan, J.-T.; Cheng, T.-J. R.; Cheng, Y.-S. E. Enhanced Anti-influenza Agents Conjugated with Anti-inflammatory Activity. 翁啟惠、方俊民、柳公政、詹家琮、鄭義循、鄭婷仁，與抗炎活性偶聯的增強的抗流感劑。

12-1.

Japan patent JP6174117B2, issued on August 2, 2017.

12-2.

中國專利CN104640540B, issued on October 9, 2018.

12-3.

US patent US10130714B2, issued on November 20, 2018.

13

Lin, J.-H.; Chen, C.-C.; Fang, J.-M.; Chen, J.-B.; Chen, T.-R.; Wei, T.-T. 3,5-N-Trihydroxy-alkanamide and Derivatives: Method for Making Same and Use Thereof. 林榮信、方俊民、陳青周、陳庭榕、陳志彬、魏子堂，「3,5-N-三羥烷醯胺及其之衍生物、其之製造方法與用途」。

13-1.

中華民國(台灣)專利 I455912號, issued on October 11, 2014.

13-2.

US patent US9,353,061B2, issued on May 31, 2016.

13-3.

Europe patent EP2874994B1, issued on Jan 8, 2020.

14

Wong, C.-H.; Fang, J.-M.; Cheng, Y.-S. E.; Tsai, C.-S. Cell-Permeable Probes for Identification and Imaging of Sialidases.

14-1.

Japan patent JP6302909B2, issued on March 9, 2018.

14-2.

US patent US10214765B2, issued on February 26, 2019.

15

Wong, C.-H.; Fang, J.-M.; Shie, J.-J. Benzocyclooctyne Compounds and Use Thereof.

15-1.

US patent US9547009B2, issued on January 17, 2017.

15-2.

Japan patent JP6211084B2, issued on October 11, 2017.

16

Lin, J.-H.; Chen, C.-C.; Fang, J.-M.; Chen, J.-B.; Chern, T.-R.; Wei, T.-T. Dual-action Inhibitors against Histone Deacetylases and 3-Hydroxy-3-methylglutaryl Coenzyme Reductase. 林榮信、陳青周、方俊民、陳志彬、陳庭榕、魏子堂，「抗組蛋白去乙醯酶及3-羥-3-甲基戊二輔酶A還原酶之雙重作用抑制劑」。

16-1.

US patent US9115116B2, issued on August 25, 2015.

16-2.

中華民國專利TWI537280B, issued on June 11, 2016.

17

Fang, J.-M.; Lin, Y.-L.; Lin, J.-H.; Lin, C.-J.; Chern, Y.; Huang, N.-K.; Wang, H.-L.; Tu, B. P.-H.; Chen, C.-C. Compounds for Use in Prevention and Treatment of Neurodegenerative Diseases and Pain. 方俊民、林雲蓮、林榮信、林君榮、陳儀莊、黃乃瑰、王鴻利、杜邦憲、陳志成，「用於預防和治療神經退行性疾病和疼痛的化合物」。

17-1.

European patent EP3060566B1, issued on September 5, 2018.

17-2.

中國專利 CN106414456B, issued 14 December 2018.

17-3.

Australia patent AU2014340114B2, issued on October 18, 2018.

17-4.

Israel patent IL245103A, issued on February 28, 2019.

17-5.

中華民國(台灣)專利核定，

17-6.

US patent US10301348B2, issued on May 28, 2019.

17-7.

South Africa patent allowed,

17-8.

Japan patent JP6534997B2, issued on June 26, 2019.

18

Chen, C.-C.; Fang, J.-M. Combined Treatment of 3,5-N-Trihydroxy-alkanamide or 3,5-N-Trihydroxy-6-alkenamide Derivative and Chemotherapeutic Agent. US patent application, 2014.

19

Fang, J.-M.; Hsu, C.-S. Compositions and Methods for the Preparation of 4-Oxy-2-cyclohexenone and 6-Oxy-2-cyclohexenone Compounds, PCT patent application, 2015 (priority claim 2014).

20

Wong, C.-H.; Fang, J.-M.; Shie, J.-J. Reactive Labelling Compounds and Uses Thereof. US patent application, 2015.

20-1.

US patent US10119972B2, issued on November 6, 2018.

20-2.

Japan patent JP6562942B2, issued on August 28, 2019.

21

Wong, C.-H.; Yang, P.-C.; Fang, J.-M.; Pan, S.-H.; Cheng, T.-J. R.; Li, L.-W. Purine Compounds Possessing Anticancer Activity. PCT patent application, 2017 (priority claim 2016). WO2017136689A1

21-1.

台灣發明專利第106103823號，06 Feb 2017. TW201738245A.發明專利第I722106號，具有抗癌活性之嘌呤化合物，Issued on 21 March 2021.

21-2.

US patent application, 03 Aug 2018. US20180369249A1. US 10,765,681 B2, issued on 8 Sept 2020.

21-3.

中國專利申請，2018. CN108602825A

22

Lu, L.; Wang, C.-H.; Fan, K.-S.; Wang, C.-D.; Fang, J.-M. Method of Making Inorganic Gold Compounds. 盧凌、王振翔、范貴盛、王證鼎、方俊民，「無機金化合物的製法」。

22-1.

US patent US10046976B1, issued on June, 2017.

22-2.

中華民國(台灣)專利 TWI626217B, issued on June 11, 2018.

22-3.

Japan patent JP6606149, issued on 25 October 2019.

22-4.

UK patent GB2558982A, allowed, 2018.

22-5.

German patent DE102017123714A1, allowed, 2018.

23

Chen, C.-C.; Fang, J.-M.; Lee, C.-H.; Chang, J.-Y. Compound with Analgesic Effect for Use in Prevention and Treatment of Pain. US patent application, 2017. 陳志成、方俊民、李政翰、張仁垚，「用於預防及治療疼痛之具有止痛效果的化合物」。

23-1.

中華民國(台灣)專利 I670065，issued on 1 September 2019.

24

Lu, L.; Fan, K.-S.; Wang, C.-H.; Chiu, C.-L.; Chang, T.-W.; Wang, C.-D.; Fang, J.-M. Method of Making Colloidal Metal Nanoparticles. 盧凌、范貴盛、王振翔、邱群倫、張大為、王證鼎、方俊民，「金屬奈米粒子膠體溶液的製法」。

24-1.

US patent US10099191B1, Issued on October, 2018.

24-2.

中華民國(台灣)專利 I648099，Issued on 21 January 2019.

24-3.

Australia patent 2018201824, allowed 2019.

25

Lu, L.; Fan, K.-S.; Chiu, C.-L.; Yen, H.-W.; Hsu, H.-C.; Lin, C.-Y.; Peng, C.-J.; Wang, C.-D.; Fang, J.-M. Method of Making Colloidal Platinum Nanoparticles. 盧凌、范貴盛、邱群倫、閻涵武、許浩展、林佳儀、彭啟鈞、王證鼎、方俊民，「製備鉑奈米粒子膠體溶液的方法」。

26

Lu, L.; Fan, K.-S.; Chiu, C.-L.; Yen, H.-W.; Peng, C.-J.; Wang, C.-D.; Fang, J.-M. Method of Making Inorganic Platinum Compound. 盧凌、范貴盛、邱群倫、閻涵武、彭啟鈞、王證鼎、方俊民，「無機鉑化合物的製法」。

26-1.

中華民國(台灣)專利 allowed on 21 June 2019.

26-2.

Australian patent 2019202878, allowed Dec, 2019.