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Department of Chemistry


CHEN, Chao-Tsen

CHEN, Chao-Tsen
Room A607, Chemistry Building
Fax: +886-2-3366-8671
Research Interest

  • Developing steroid-conjugate photoaffinity/fluorescent probes to decipher the steroid biological roles.

  • Developing DNA-specific alkylating agents as potential therapeutic drugs.

  • Developing theranostic drug delivery systems.

  • Developing stimuli responsive materials including optoelectronics/prodrugs.

Career and Service Experiences

  • B.S., 1986, Department of Chemistry, National Taiwan University; Ph.D., 1993, Department of Chemistry, University of California-San Diego; Research Fellow, 1994-1995, Caltech; Postdoctoral Fellow, 1995-1997, Columbia.

  • Assistant Professor, 1997-2003; Associate Professor, 2003-2006; Professor, 2006-present, Department of Chemistry, National Taiwan University.

  • Director of Strategic Planning at Office of Research & Development, 2009.09-2011.01, National Taiwan University.

  • Director of Instrument Center, 2011.08-2014.08, National Taiwan University.

  • Coordinator of Discipline of Chemistry, 2016.7-present, Ministry of Science and Technology, Taiwan.

Honors and Awards

  • 2004 Academia Sinica Young Investigator Research Paper Award

  • 2004 National Taiwan University Research Award

  • 2007 Asia Core Program (ACP) Lectureship Award

  • 2008 Thieme Journal Award and the Synlett and Synthesis.

Research Content
Selected Publications

  1. Singh, R.; Chen, D.-G.; Wang, C.-H.; Lan, Y.-C.; Liu, Y.-H.; Chou, P.-T.*; Chen, C.-T.* “Tailoring C-6-Substituted Coumarin Scaffolds for Novel Photophysical Properties and Stimuli-Responsive Chromism” J. Chem. Phys. B 2021, 125, 41, 11557–11565.

  2. Wang, C.-H.; Liu, Z.-Y.; Huang, C.-H.; Chen, C.-T.*; Meng, F.-Y.; Liao, Y.-C.; Liu, Y.-H.; Chang, C.-C.; Li, E. Y.* and Chou, P.-T.* “Chapter Open for the Excited-State Intramolecular Thiol Proton Transfer in the Room-Temperature Solution” J. Am. Chem. Soc. 2021, 143, 12715−12724.

  3. Lee, Y.-T.; Tseng, P.-C.; Komino, T.; Mamada, M.; Ortiz, R. J.; Leung, M.-k.; Chiu, T.-L.; Lin, C.-F. ; Lee, J.-H. Lee;* Adachi, C.; Chen, C.-T.* and Chen, C.-T.* “Simple molecular-engineering approach for enhancing orientation and out-coupling efficiency of thermally activated delayed fluorescent emitters without red-shifting emission” ACS Appl. Mater. Interfaces 2018, 10, 43842−43849

  4. Chen, H.-Y.; Lin, C.-W.; Chen, C.-T.;* Chen, C.-T.;* Golder, J.; Lan, Y.-B.; Wang, J.-K.* “Polymer side-chain substituents elucidate thermochromism of benzodithiophene-dithiophenylacrylonitrile copolytmers – polymer solubility correlation of thermochromism and photovoltaic performance”Polym. Chem. 2017, 8, 3689.

  5. Lee, Y.-T.; Chang, Y.-T.; Chen, C.-T.*; Chen, C.-T.*“The first aggregation-induced emission fluorophore as a solution processed host material in hybrid white organic light-emitting diodes” J. Mater. Chem. C 2016, 4, 7020.

  6. Chen, C.-H.; Hu, T.-H.; Huang, T.-C.; Chen, Y.-L.; Chen, Y.-R.; Cheng, C.-C*; Chen, C.-T*. “Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates” Chem. Eur. J. 2015, 21, 17379.

  7. Fu, Y.-H.; Chen, C.-Y.; Chen, C.-T.* “Tuning of hydrogen peroxide-responsive polymeric micelles of biodegradable triblock polycarbonates as a potential drug delivery platform with ratiometric fluorescence signaling” Polym. Chem. 2015, 6, 8132.

  8. Chen, C.-Y.; Chen, C.-T.* “Reaction-Based and Single Fluorescent Emitter-Decorated Ratiometric Nanoprobe to Detect Hydrogen Peroxide” Chem. Eur. J. 2013, 19, 16050.

  9. Weng, J.-H.; Liang, M.-R.; Chen, C.-H., Huang, T.-C.; Chen, Y.-R.; Tong, S.-K.; Lee, S.-P.; Chen, C.-T.*; Chung, B.-c.* “Pregnenolone changes CLIP-170 conformation to promote microtubule polymerization and cell migration” Nature-Chem. Biol. 2013, 9, 636-642.

  10. Lin, Y.-C.; C.-T. Chen* “Alkaline Earth Ion-Induced Coil-Helix-Coil Transition of Lysine-Coumarin-Azacrown Hybrid Foldamers with OFF-OFF-ON Fluorescence Switching” Chem. Eur. J. 2013, 19, 253.

Update: 2022-01-25