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Department of Chemistry


LIN, Chun-Hung

LIN, Chun-Hung
Professor (joint appointment)
Room 802, Institute of Biologi
Fax: +886-2-2651-4705
Research Interest

  • Carbohydrate-related enzymes, in particular in association with diseases

  • Protein cysteine modification linked to redox regulation

Career and Service Experiences

  • B.S., 1990, National Taiwan University.

  • Ph.D., 1995, Scripps Research Institute.

  • Research Fellow, 1997, Harvard Medical School.

  • Assistant Research Fellow, 1997-2002, the Institute of Biological Chemistry, Academia Sinica.

  • Associate Research Fellow, 2002-2007, the Institute of Biological Chemistry,  Academia Sinica.

  • Research Fellow, 2007-present, the Institute of Biological Chemistry,  Academia Sinica.

  • Adjunt Professor, 2015-present, National Taiwan University.

Honors and Awards

  • Glaxo Fellowship, 1993-1994

  • Heritage Prize and Fellowship of the Lee Foundation,

  • A co-recipient of the 2000 Presidential Green Chemistry Challenge Award honoring C.-H. Wong

  • Mentor Recognition Award 2005, University of California at San Diego (UCSD)

  • Excellent Young Scientist (from the Chemical Society at Taipei), 2006

  • The Distinguished Lectureship Award of the Asian International Symposium by the Chemical Society of Japan, 2007

  • Selected as one of The 2008 Top 10 Rising Stars in Taiwan by the Central News Agency of Taiwan

  • Young Affiliate of TWAS (The Academy of Sciences for the Developing World) ,2008-2012

  • The 2009 Lectureship Award to visit Japan supported by Asian Core Program

  • The 2010 Young Scholar Award of Tien-De Li Biomedical Foundation

  • The 2010 Yong Investigator Award of Academia Sinica

  • Investigator Award of Academia Sinica, 2011

  • The 2011 Lectureship Award to visit Korea supported by Asian Core Program

  • 2014 Outstanding Research Award of National Science Council

Selected Publications

  1. Yu-Nong Lin, Daniel Stein, Sheng-Wei Lin, Sue-Ming Chang, Ting-Chien Lin, Yu-Ruei Chuang, Jacquelyn Gervay-Hague, Hisashi Narimatsu, Chun-Hung Lin* “Chemoenzymatic Synthesis of GDP-l-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors.” Advanced Synthesis & Catalysis2012.

  2. C.-M. Chong, S. Gao, B.-Y. Chiang, W.-H. Hsu, T.-C. Lin, T.-C. Chen, C.-H. Lin* “ An Acyloxymethyl Ketone-based Probe to Monitor the Activity of Glutathionylspermidine Amidase in Escherichia coli.” ChemBioChem2011.

  3. H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, C.-H Lin, A.H.-J.Wang “Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range.” Angewandte Chemie-International Edition2010.

  4. Chiang BY, Chen TC, Pai CH, Chou CC, Chen HH, Ko TP, Hsu WH, Chang CY, Wu WF, Wang AH, Lin CH “Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION.” Journal of Biological Chemistry2010.

  5. Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin “Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells.” Proc. Natl. Acad. Sci. USA2009.

  6. D. B. Stein, Yu Nong. Lin, Chun Hung Lin* “Characterization of Helicobacter pylori α1,2-Fucosyltransferase for Enzymatic Syntehsis of Tumor-Associated Antigens.” Adv. Synth. Catal.2008.

  7. H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin “Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.” J Biol Chem2007.

  8. C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin “Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase.” EMBO J2006.

  9. C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong and C. H. Lin “Discovery of Picomolar Slow Tight-Binding Inhibitors of alpha-Fucosidase.” Chemistry & Biology2004.

  10. C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin “Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.”Angewandte Chemie-International Edition2003.

Update: 2021-11-19