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Department of Chemistry


CHU, Chung-Han (John)

CHU, Chung-Han (John)
Assistant Professor
Room A521, Chemistry Building
Fax: +886-2-3366-8671
Research Interest

  • Nonribosomal peptide (NRP) structure prediction

  • Synthesis and evaluation of NRPs

  • Bioactivity screening of natural products

  • Antibacterial and anticancer drug discovery

Career and Service Experiences

  • B.S., 2004, Department of Chemistry, National Taiwan University

  • Ph.D., 2005-2011 The Scripps Research Institute

  • Postdoctoral Fellow, 2011-2014 Yale University

  • Postdoctoral Associate, 2014-2019 Rockefeller University

  • Assistant Professor, 2019-present, Department of Chemistry, National Taiwan University

Honors and Awards

  • 2019 Outstanding Research Award for New Faculty, Department of Chemistry, National Taiwan University

  • 2018 Rockefeller University Postdoctoral Association Career Development Award

  • 2013 Yale University Postdoctoral Scholar Travel Fund

  • 2011 Camille & Henry Dreyfus Environmental Chemistry Postdoctoral Fellowship

  • 2004 Dr. An-Tai Chen Distinguished Research Scholarship

Research Content
Selected Publications

* Denotes equal contribution

  1. Wu, CH; Chu, J. Total synthesis and biological evaluation of pagoamide A. Front. Chem. 2021, 9: 741290.

  2. Chu, J; Koirala, B; Forelli, N; Vila-Farres, X; Ternei, MA; Ali, T; Colosimo, DA; Brady, SF. “Synthetic-bioinformatic natural product antibiotics with diverse modes of action.”  J. Am. Chem. Soc. 2020142, 14158

  3. Chu, J; Vila-Farres, X; Brady, SF. “Bioactive synthetic-bioinformatic natural product cyclic peptides inspired by nonribosomal peptide synthetase gene clusters from the human microbiome.”  J. Am. Chem. Soc. 2019141, 15737

  4. *Vila-Farres, X; *Chu, J; Ternei, MA; Lemetre, C; Park, S; Perlin, DS; Brady, SF “An optimized synthetic-bioinformatic natural product antibiotic sterilizes multidrug-resistant Acinetobacter baumannii-infected wounds.” mSphere 2018, 3, e00528-17.

  5. *Chu, J; *Vila-Farres, X; Inoyama, D; Gallardo-Macias, R; Jaskowski, M; Satish, S; Freudlich, JS; Brady, SF “Human microbiome inspired antibiotics with improved β-lactam synergy against MDR Staphylococcus aureus.” ACS Infect. Dis. 2018, 4, 33.

  6. Cohen, LJ; Esterhazy, D; Kim, SH; Lemetre, C; Aguilar, RR; Gordon, EA; Pickard, AJ; Cross, JR; Emiliano, AB; Han, SM; Chu, J; Vila-Farres, X; Kaplitt, J; Rogoz, A; Calle, P; Hunter, C; Bitok, JK; Brady, SF “Commensal bacteria make GPCR ligands that mimic human signaling molecules.” Nature 2017, 549, 48.

  7. *Vila-Farres, X; *Chu, J; Inoyama, D; Ternei, MA; Lemetre, C; Cohen, LJ; Cho, W; Reddy, BVB; Zebroski, HA; Freudlich, JS; Perlin, DS; Brady, SF “Antimicrobials inspired by nonribosomal peptide synthetase gene clusters.” J. Am. Chem. Soc. 2017, 139, 1404.

  8. *Chu, J; *Vila-Farres, X; Inoyama, D; Ternei, MA; Cohen, LJ; Gordon, EA; Reddy, BVB; Charlop-Powers, Z; Zebroski, HA; Gallardo-Macias, R; Jaskowski, M; Satish, S; Park S; Perlin, DS; Freudlich, JS; Brady, SF “Discovery of MRSA active antibiotics using primary sequence from the human microbiome.” Nat. Chem. Biol. 2016, 12, 1004.

Update: 2022-01-26