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Department of Chemistry


LO, Lee-Chiang

LO, Lee-Chiang
Room B773, Chemistry Building
Fax: +886-2-3366-8671
Research Interest

  • Development of fluorous reagents for green chemistry applications.

  • Development of molecular tools for biochemical applications.

Career and Service Experiences

  • B.S., 1983, Department of Chemistry, National Taiwan University.

  • M.S., 1985, Institute of Biochemical Sciences, National Taiwan University.

  • Ph.D., 1993, Department of Chemistry, Columbia University.

  • Postdoctoral Fellow, 1993-1996, The Scripps Research Institue.

  • Associate Professor, 1996-2005; Professor, 2005-present, Department of Chemistry, National Taiwan University.

Honors and Awards

  • National Taiwan University Award for Outstanding Teaching, 2005 and 2012.

Research Content
Selected Publications

  1. Shi, T.-H.; Huang, Y.-L.; Chen, C.-C.; Pi, W.-C.; Hsu, Y.-L.; Lo, L.-C.; Chen, W.-Y.; Fu, S.-L.; Lin, C.-H.* “ Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage”, Biochem. Biophys. Res. Commun. 2020, 533, 467-473.

  2. Cheng W.-C; Liu W.-J; Hu K.-H; Tan Y.-L; Lin Y.-T; Chen W.-A; Lo, L.-C.* ” Rapid Synthesis of a Natural Product-Inspired Uridine Containing Library”, ACS Comb. Sci. 2020, 22, 600-607.

  3. Hsu, Y.-H.; Hsu, Y.-L.; Liu, S.-H.; Liao, H.-C.; Lee, P.-X.; Lin, C.-H.; Lo, L.-C.*; Fu. S.-L.* Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study”, PLoS ONE 2016, 11, e0152770.

  4. Hsu, Y.-L.; Yang, C.-C.; Chou, T.-C.; Tai, C.-H.; Chen, L.-Y.; Fu, S.-L.; Lin, J.-J.*; Lo, L.-C.* “Design, Synthesis, and Evaluation of Cell Permeable Probes for Protein Kinases”, Tetrahedron 2016, 72, 58-68.

  5. Hsu, Y.-L.; Nandakumar, M.; Lai, H.-Y.; Chou, T.-C.; Chu, C.-Y.; Lin, C.-H.*; Lo, L.-C.* “Development of Activity-Based Probes for Imaging Human -L-Fucosidases in Cells”, Org. Chem. 2015, 80, 8458-8463.

  6. Tai, C.-H.; Lu, C.-P.; Wu, S.-H.*; Lo, L.-C.* “Synthesis and Evaluation of Turn-on Fluorescent Probes for Imaging Steroid Sulfatase Activities in Cells”, Commun. 2014, 50, 6116-6119.

  7. Ang, W. J.; Chu, C.-Y.; Chou, T.-C.; Lo, L.-C.*; Lam, Y.* “Application of a Recyclable Fluorous Oxime in the Convenient Synthesis of 3-Amino-1,2-Benzisoxazoles and 4-Amino-1H-2,3-Benzoxazines”, Green Chem. 2013, 15, 780–785.

  8. Chu, C.-Y.; Chang, C.-P.; Chou, Y.-T.; Handoko; Hu, Y.-L.; Lo, L.-C.*; Lin, J.-J.* “Development and Evaluation of Novel Phosphotyrosine Mimetic Inhibitors Targeting the Src Homology 2 Domain of Signaling Lymphocytic Activation Molecule (SLAM) Associated Protein”, Med. Chem. 2013, 56, 2841–2949.

  9. Susanto, W.; Chu, C.-Y.; Ang, W. J.; Chou, T.-C.; Lo, L.-C.*; Lam, Y.* “Fluorous Oxime Palladacycle: A Precatalyst for Carbon−Carbon Coupling Reactions in Aqueous and Organic Medium” Org. Chem. 2012, 77, 2729–2742.

  10. Susanto, W.; Chu, C.-Y.; Ang, W. J.; Chou, T.-C.; Lo, L.-C.*; Lam, Y.* “Development of a Fluorous, Oxime-Based Palladacycle for Microwave-Promoted Carbon-Carbon Coupling Reactions in Aqueous Media” Green Chem. 2012, 14, 77–80.

  11. Lu, C.-P.; Ren, C.-T.; Lai, Y.-N.; Wu, S.-H.*; Wang, W.-M.; Chen, J.-Y.; Lo, L.-C.* “Design of a Mechanism-Based Probe for Neuraminidase to Capture Influenza Viruses” Chem. Int. Ed. 2005, 44, 7048–7052.

  12. Chu, C.-Y.; Lo, L.-C.* Development of Highly Selective and Sensitive Probes for Hydrogen Peroxide”, Commun. 2003, 2728-2729.

  13. Lo, L.-C.*; Pang, T.-L.; Kuo, C.-H.; Chiang, Y.-L.; Wang, H.-Y.; Lin, J.-J.* “Design and Synthesis of Class-Selective Activity Probes for Protein Tyrosine Phosphatases”, Proteome Res. 2002, 1, 35-40.

Update: 2022-01-26