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Department of Chemistry


Manuel Maestre-Reyna

Manuel Maestre-Reyna
Assistant Professor
Room B477, Chemistry Building
Research Interest

  • Structural enzymology

  • Time-resolved structural analysis

  • Photochemistry and photobiology of light-driven enzymes

  • Developement of X-ray crystallographic techniques and analysis methods

Career and Service Experiences

  • M.S. Biochemistry, 2005, Department of Biology, Valencia University, Spain

  • Research Assitant, 2006, Department of Chemistry, Philipps University Marburg, Germany

  • Ph.D., 2011, Department of Chemistry, Philipps University Marburg, Germany

  • Lab leader, 2011-2012, Department of Chemistry, Philipps University Marburg, Germany

  • Postdoctoral research fellow, 2012-2016, Institute of Biological Chemistry, Academia Sinica, Taiwan

  • Visiting Assitant Professor, 2016-2022, Taiwan Protein Project, Institute of Biological Chemistry, Academia Sinica, Taiwan

  • Assistant Professor, 2022-present, Department of Chemistry, National Taiwan University, Taiwan

Honors and Awards

  • Academia Sinica Postdoctoral fellowship. 2013–2015.

  • Best presentation award at the CNDY 2013 workshop. 2013.

  • 3rd prize in the poster contest during the IITC Symposium. 2011.

  • DAAD La Caixa grant for Spanish post-graduate students in Germany. 2006-2008.

  • Excellence Prize in the E-MeP-Lab Master class workshop “System approaches to membrane proteins”. 2007

Research Content
Selected Publications

  1. Maestre-Reyna M, Yang C-H, Nango E, Hang W-C, Putu EPGN, Wu W-J, Wang P-H, Franz-Badur S, Saft M, Emmerich H-J, Wu H-Y, Lee C-C, Huang K-F, Chang Y-K, Liao J-H, Weng J-H, Gad W, Chang C-W, Pang AH, Sugahara M, Owada S, Hosokawa Y, Joti Y, Yamashita A, Tanaka R, Tanaka T, Luo FJ, Tono K, Kiontke S, Schapiro I, Spadacini R, Royant, A, Yamamoto J, Iwata S, Essen L-O*, Bessho Y*, Tsai M-D*. Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme. 2022 Nature Chemistry 14, 677–685.

  2. Maestre-Reyna M, Huang W-C, Wu W-J, Singh PK, Hartmann R, Wang P-H, Lee C-C, Hikima T, Yamamoto M, Bessho Y, Drescher K, Tsai M-D, Wang AH-J*, Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate-dependent autoproteolysis activity. 2021 IUBMB Life. 73, 418–431.

  3. LinWu S-W, Tu Y-H, Tsai T-Y, Maestre-Reyna M, Liu M-S, Wu W-J, Huang J-Y, Chi H-W, Chang W-H, Chiou C-F, Wang A-HJ, Lee J*, Tsai M-D*, Thermococcus sp. 9°N DNA polymerase exhibits 3′-esterase activity that can be harnessed for DNA sequencing. Communications Biology 2019 Jun; 2, 224.

  4. Franz S, Ignatz E, Zielosko H, Putu EPGN, Maestre-Reyna M, Tsai M-D, Yamamoto J, Mittag M, Essen L-O*, Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii. Nucleic Acid Research. 2018 Sep; 6;46(15):8010-8022.

  5. Maestre-Reyna M, Yamamoto J, Huang W-C, Tsai M-D, Essen L-O, Bessho Y*, Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA. IUCrJ. 2018 Aug; 5(Pt 5):608-618.

  6. Lee, C-C+, Maestre-Reyna, M+, Hsu, K-C, Wang, H-C, Liu, C-I, Jeng, W-Y, Lin, L-L, Wood, R, Chou, C-C, Yang, J-M, Wang, AH-J.* Crowning Proteins: Modulating the Protein Surface Properties using Crown Ethers. Ang. Chem. Int. Ed. 2014 Oct; 53(48):13054-8

  7. Maestre-Reyna, M, Diderrich, R, Veelders, M S, Eulenburg, G, Kalugin, V, Brückner, S, Keller, P, Rupp, S, Moesch, H-U*, Essen L-O.* Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia. PNAS 2012 Sep; 109(42):16864-9

Update: 2024-05-23