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Department of Chemistry


WONG, Chi-Huey

WONG, Chi-Huey
Distinguished Chair Professor for Research
Genomics Research Center, Academia Sinica
Fax: +886-2-2789-9927
Research Interest

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting proteins and RNA has been performed to investigate the function of those molecules. Programmable one-pot reactions are being developed for the synthesis of complex oligosaccharides and glycan arrays and compliment new chemo-enzymatic strategies for the assembly of glycoproteins and other biologically active molecules for structural and functional studies. 

Career and Service Experiences

  • B.S. & M.S., 1977, National Taiwan University.

  • Ph.D., 1982, Organic Chemistry, Massachusetts Institute of Technology.

  • Postdoctoral Fellow, 1982-1983, Harvard University.

  • Assistant Professor through Professor of Chemistry and Biochemistry, 1983-1989, Texas A&M University.

  • Ernest W. Hahn Professor of Chemistry, The Scripps Research Institute, 1989-2006.

  • Distinguished Research Fellow and Director, The Genomic Research Center, Academia Sinica, 2003-2006.

  • President, Academia Sinica, 2006-2016.

  • Joint Appointment: Distinguished Professor of Chemistry and Biochemical Sciences, National Taiwan University, 2003-present.

Honors and Awards

  • Presidential Young Investigator Award in Chemistry, 1986

  • The IUPAC International Carbohydrate Award, 1994

  • Elected Member of Academia Sinica, Taipei, 1994

  • Elected Member of the American Academy of Arts and Sciences, 1996

  • American Chemical Society Harrison Howe Award in Chemistry,1998

  • American Chemical Society Claude S. Hudson Award in Carbohydrate Chemistry, 1999

  • The International Enzyme Engineering Award, 1999

  • The Presidential Green Chemistry Challenge Award, USA, 2000

  • Scientific Advisor of Max-Planck-Institut, Germany, 2000-2008

  • Elected Member of the US National Academy of Sciences, 2002

  • American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 2005

  • The American Chemical Society Arthur C. Cope Award, 2012

  • Nikkei Asia Prize for Science, Technology and Innovation, 2012

  • The Wolf Prize in Chemistry, 2014

  • The Royal Society of Chemistry Robert Robinson Award, 2015.

Research Content
Selected Publications

  1. Koeller, K. M.; Wong, C.-H.* "Enzymes for chemical synthesis" Nature 2001, 409, 232–240.

  2. Sears, P.; Wong, C.-H.* "Toward automated synthesis of oligosaccharides and glycoproteins" Science 2001, 291, 2344–2350.

  3. Brik, A.; Yang, Y.-Y.; Ficht, S.; Wong C.-H.* "Sugar-Assisted Glycopeptide Ligation" Am. Chem. Soc. 2006, 128, 5626-5627.

  4. Hsu, T.-L.; Hanson, S. R.; Kishikawa, K.; Wang, S.-K.; Sawa, M.; Wong, C.-H.* "Alkynyl Sugar Analogs for the Labeling and Visualization of Glycoconjugates in Cells" Nat. Acad. Sci. U.S.A. 2007, 104, 2614-2619.

  5. Chu, K.-C.; Ren, C.-T.; Lu, C.-P.; Hsu, C.-H.; Sun, T.-H.; Han, J.-L.; Pal, B.; Chao, T.-A.; Lin, Y.-F.; Wu, S.-H.; Wong, C.-H.*; Wu, C.-Y. "Efficient and Stereoselective Synthesis of α(2→9)Oligosialic Acids: From Monomers to Dodecamers" Angew. Int. Ed. 2011, 50, 9391-9395.

  6. Huang, C.-Y.; Shih, H.-W.; Lin, L-Y.; Tien, Y.-W.; Cheng, T.-J. R.; Cheng, W.-C.; Wong, C.-H.*; Ma, C. "Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis" Nat. Acad. Sci. U.S.A. 2012, 109, 6496-6501.

  7. Shivatare, S. S.; Chang, S.-H.; Tsai, T.-I.; Tseng, S. Y.; Lin, Y.-S.; Cheng, Y.-Y.; Ren, C.-T.; Pawar, S.; Tsai, C.-S.; Shi, H.-W.; Zeng, Y.-F.; Liang, C.-H.; Kwong, P. D.; Burton, D. R.; Wu, C.-Y.; Wong, C.-H. "Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies" Nature Chemistry 2016, 8, 338-46.

Update: 2021-12-21