Department of Chemistry

• Organic Synthesis, Chemical Biology, Biochemistry, Cell Biology and Microbiology


• Development of New Diagnostic and Therapeutic Agents, Drugs and Inhibitors


• Development of New Multi-functional Biological Agents and Materials


• Study and Applications of Natural Products and Secondary Metabolites


• Proteomic and Imaging Tools to Study Microbiome and Intercellular Heterogeneity


• Expanding organic transformations with aqueous compatibility and biological orthogonality: A new paradigm for drug development, bioconjugation, and beyond.


• New functional moieties and strategies for spatiotemporal controlling and tracking for biological applications


• Novel aqueous compatible conjugation reactions to construct multifunctional and responsive probes & drugs

• B.S., 2001, Department of Chemistry, National Taiwan University.


• M.S., 2006, Department of Chemistry and Chemical Biology, Harvard University.


• Ph.D., 2011, Department of Chemistry and Chemical Biology, Harvard University.


• Postdoctoral Fellow, 2011-2013, the Scripps Research Institute.


• Assistant Professor, 2013-2018, Department of Chemistry, National Taiwan University.


• Associate Professor, 2018-2026, Department of Chemistry, National Taiwan University.


• Professor, 2026-present, Department of Chemistry, National Taiwan University.

• Outstanding Teaching Award, 2021; National Taiwan University


• Excellent Teaching Award, 2020; National Taiwan University


• 2018, Asian Core Program Lectureship Award (Japan)


• 2018 Asian Core Program Lectureship Award (Hong Kong)


• Excellent Teaching Award, 2017; National Taiwan University


• Excellent Teaching Award, 2016; National Taiwan University

Publications at National Taiwan University:

1. Kaswan, K.; Khan, A.; Chatterjee, S.; Ray, M.; Haji, H. S.; Joshi, R.; Pal, A.; Wang, T.-S. A.; Chu, J. P.; Lin, Z.-H. “Glassy Metallic Nanotube Arrays-Based Solid-Liquid Triboelectric Nanosensor for Wastewater Contaminants Sensing and Its Treatment by Thermocatalysts” Adv. Funct. Mater. 2025, e26347.


2. Lin, Z.-J.; Fang, C.-Y.; Wang, T.-S. A.* “Natural and artificial siderophores: Iron-based applications and beyond” Curr. Opin. Chem. Biol. 2025, 87, 102601.


3. Pal, A.; Suresh, S.; Khan, A.; Kuo, L. H.; Chi, L. T.; Ganguly, A.; Kao, C.-Y.; Sharma, M. K.; Wang, T.-S. A.; Kang, D.-Y.; Lin, Z.-H. “Metal-Organic Frameworks as Thermocatalysts for Hydrogen Peroxide Generation and Environmental Antibacterial Applications” Sci. Adv. 2025, 11, eads4711.


4. Kao, C.-Y.; Chen, Y.-W.; Liu, Y.-C.; Wei, J.-H.; Wang, T.-S. A.* “Versatile Stimuli-Responsive Controlled Release of Pinanediol-Caged Boronic Esters for Spatiotemporal and Nitroreductase-Selective Glucose Bio-imaging” ACS Sens. 2025, 10, 470- 479.


5. Chen, A.-L.; Lin, Z.-J.; Chang, H.-Y.; Wang, T.-S. A.* “Chemo- selective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo” J. Am. Chem. Soc. 2025, 147, 1518-1528.


6. Lin, S.-T.; Wang, C.-H.; Chen, A.-L.; Wang, T.-S. A.* “Utilizing Alkyne-Nitrone Cycloaddition for the Convenient Multi-Component Assembly of Protein Degraders and Biological Probes” Chem. Eur. J., 2024, 31, e202403184.


7. Wang, T.-S. A.*; Chen, P.-L.; Chen, Y.-C. S.; Chiu, Y.-W.; Lin, Z.-J.; Kao, C.-Y.; Hung, H.-M. “Evaluation of the Stereochemistry of Staphyloferrin A for Developing Staphylococcus-Specific Targeting Conjugates” ChemBioChem 2024, 25, e202400480.


8. Tsai, C.-Y.; Chen, P.-H.; Chen, A.-L.; Wang, T.-S. A.* “Spatiotemporal Investigation of Intercellular Heterogeneity via Multiple Photocaged Probes” Chem. Eur. J. 2023, 29, e202301067.


9. Wang, T.-S. A.*; Zhang, Y.-W.; Chen, H.-A.; Lin, S.-T.; Lee, H.-M. “Constructing pH-Responsive and Tunable Azo-Phenol-Based o-Nitrobenzyl Photocages” Chem. Eur. J. 2023, 29, e202300884.


10. Io, W.-S.; Wang, T.-S. A.* “A Versatile Strategy to Manipulate and Probe Native Carbonic Anhydrases In Cellulo Utilizing Two-Step Ligand-Directed Functionalization” ACS Chem. Biol. 2023, 18, 1208-1217.


11. Hung, H.-M.; Wang, T.-S. A.* “A Double Photocage Strategy to Construct Light-Controllable and Spatiotemporally Trackable Cathepsin B Activity-Based Probes” ACS Chem. Biol. 2022, 17, 11-16.


12. Wang, T.-S. A.*; Chen, P.-L.; Chen, Y.-C. S.; Hung, H.-M.; Huang, J.-Y. “Selectively Targeting and Differentiating Vancomycin-Resistant Staphylococcus aureus via Dual Synthetic Fluorescent Probes” ACS Infect. Dis. 2021, 7, 2584-2590.


13. Fan, C.-H.; Wei, K.-C.; Chiu, N.-H.; Liao, E.-C.; Wang, H.-C.; Wu, R.-Y., Ho, Y.-J.; Chan, H.-L.; Wang, T.-S. A.; Huang, Y.-Z.; Hsieh, T.-H.; Lin, C.-H.; Lin, Y.-C.; Yeh, C.-K. “Sonogenetic-Based Neuro- modulation for the Amelioration of Parkinson’s Disease” Nano Letters, 2021, 21, 5967-5976.


14. Wang, T.-S. A.*; Wu, R.-Y.; Hong, Y.; Wang, Z.-C.; Li, T.-L.; Shie, J.-J.; Hsu, C.-C. “Labeling and Characterization of Phenol‐Containing Glycopeptides Using Chemoselective Probes with Isotope Tags” ChemBioChem 2021, 22, 2415-2419.
    ▲ This work was highlighted as Cover Feature in the same issue


15. Chung, H.-H.; Kao, C.-Y.; Wang, T.-S. A.; Chu, J.; Pei, J.; Hsu, C. C. "Reaction Tracking and High-Throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking." Anal. Chem. 2021, 93, 2456-2463.


16. Chen, P.-C.; Ho, S.-Y.; Chen, P.-L.; Hung, T.-C.; Liang, A.-J.; Kuo, T.-F.; Huang H.-C.; Wang, T.-S. A.* “Selective Targeting of Vibrios by Fluorescent Siderophore- Based Probes” ACS Chem. Biol. 2017, 12, 2720-2724.
    ▲ This work was highlighted by Spotlight, Chem. Res. Toxicol., 2017, 30 (12), 2095–2096


17. Fan, C.-H.; Huang, Y.-S.; Huang, W.-E.; Lee, A. A.; Ho, S.-Y.; Kao, Y.-L.; Wang, C.-L.; Lian, YL.; Ueno T.; Wang, T.-S. A.; Yeh, C.-K.; Lin, Y.-C. “Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool” ACS Synth. Biol. 2017, 6, 2021-2027.


18. Ho, Y.-H.; Ho, S.-Y.; Hsu, C.-C.; Shie, J.-J.; Wang, T.-S. A.* “Utilizing an Iron(III)-Chelation Masking Strategy to Prepare Mono- and Bis-Functionalized Aerobactin Analogues for Targeting Pathogenic Bacteria” Chem. Comm. 2017, 53, 9265-9268.


19. Luo, X.; Wang, T.-S. A. (co-first author); Zhang, Y.; Wang, F.; Schultz, P. G. “Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator” Cell Chem. Biol. 2016, 23, 1098-1102.


20. Lee, A. A.; Chen, Y.-C.; Ekalestari, E.; Ho, S.-Y.; Hsu, N.-S.; Kuo, T.-F.; Wang, T.-S. A.* “Facile and Versatile Chemoenzymatic Synthesis of Enterobactin Analogues and Applications in Bacterial Detection” Angew. Chem. Int. Ed. 2016, 55, 12338-12342.


21. Tien, H.-W.; Ou, Y.-M.; Hsu R.-Y.; Wang, T.-S.; Her G.-R. “Letter: The formation of a M + 2 Compound in the Analysis of a Trimethylsilyl Derivative of Mono- carboxylic Acids by Gas Chromatography Electrospray Ionization Mass Spectrometry” Eur. J. Mass Spectrom. 2016, 22, 145-150.

Publications before joining National Taiwan University:

1. Zhang, Y.; Goswami, D.; Wang, D.; Wang, T.-S.; Sen, S.; Magliery, T. J.; Griffin, P. R.; Wang, F.; Schultz, P. G. “An Antibody with a Variable-Region Coiled-coil "Knob" Domain” Angew. Chem. Int. Ed. 2014, 53, 132-135.


2. Oman, T. J.; Lupoli, T. J.; Wang, T.-S.; Kahne, D.; Walker, S.; van der Donk, W. A. “Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry” J. Am. Chem. Soc. 2011, 133, 17544-17547.


3. Lupoli, T. J.; Tsukamoto, H.; Doud, E.; Wang, T.-S.; Walker, S.; Kahne, D. “Transpeptidase- Mediated Incorporation of D-Amino Acids” J. Am. Chem. Soc. 2011, 133, 10748-10751.


4. Wang, T.-S. (first author); Lupoli, T. J.; Sumida, Y.; Tsukamoto, H.; Wu, Y.; Rebets, Y.; Kahne, D.; Walker, S. “Primer Preactiviation of Peptidoglycan Polymerases” J. Am. Chem. Soc. 2011, 133, 8528-8530.


5. Fuse, S.; Tsukamoto, H.; Yuan, Y.; Wang T.-S.; Zhang, Y.; Bolla, M.; Walker, S.; Sliz, P.; Kahne, D. “Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin” ACS Chem. Biol. 2010, 5, 701-711.


6. Perlstein, D. L.; Wang, T.-S.; Doud, E.; Kahne, D.; Walker, S. “The Role of the Substrate Lipid in Processive Glycan Polymerization by the Peptidoglycan Glycosyltransferases” J. Am. Chem. Soc. 2010, 132, 48-49.


7. Lupoli, T. J.; Taniguchi, T.; Wang, T.-S.; Perlstein, D. L.; Walker, S.; Kahne, D. “Studying a Cell Division Amidase Using Defined Peptidoglycan Substrates” J. Am. Chem. Soc. 2009, 131, 18230-18231.


8. Wang, T.-S.; Manning, S. A.; Walker, S.; Kahne, D. “Isolated Peptidoglycan Glycosyl- transferases from Different Organisms Produce Different Glycan Chain Lengths” J. Am. Chem. Soc. 2008, 130, 14068-14069.
   ▲ This work was featured in NEWS OF THE WEEK, Chem. & Eng. News