林俊宏
合聘教授
中央研究院生物化學研究所802室
傳真: 02-2651-4705
研究興趣
- 幽門螺旋桿菌(各種胃部疾病的主要致病原)與宿主-胃部表皮細胞之間，互相溝通、對抗的交互作用
- 感染性的細菌在面對宿主免疫細胞的過氧化物攻擊時，如何發展出抗氧化的機制
- 研究免疫細胞的分化與活化，與細胞表面醣分子結構變化之關聯性
簡歷
- 1990年臺灣大學化學系學士
- 1995年史克利普斯研究所 (Scripps Res Inst)博士
- 1997年哈佛大學醫學院博士後研究
- 1998任中央研究院生物化學研究所助研究員
- 2002任中央研究院生物化學研究所副研究員
- 2007年迄今任中央研究院生物化學研究所研究員
- 2015年迄今任國立臺灣大學化學系合聘教授
榮譽事項
- 1993-1994 史克利普斯研究所葛羅素獎學金
- 1998 李氏基金會傳統學術獎
- 2002-2004 臺灣生物物理學會秘書長
- 2005 加州大學聖地牙哥分校良師成就獎
- 2006 中國化學會傑出青年獎章
- 2008 中央社遴選台灣十大潛力人物
- 2010 永信李天德醫藥基金會永信李天德青年科學家獎
- 2010 中央研究院年輕學者研究著作獎
- 2011 中央研究院中研院深耕計畫獎助
代表著作
- Yu-Nong Lin, Daniel Stein, Sheng-Wei Lin, Sue-Ming Chang, Ting-Chien Lin, Yu-Ruei Chuang, Jacquelyn Gervay-Hague, Hisashi Narimatsu, Chun-Hung Lin* “Chemoenzymatic Synthesis of GDP-l-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors.” Advanced Synthesis & Catalysis, 2012.
- C.-M. Chong, S. Gao, B.-Y. Chiang, W.-H. Hsu, T.-C. Lin, T.-C. Chen, C.-H. Lin* “ An Acyloxymethyl Ketone-based Probe to Monitor the Activity of Glutathionylspermidine Amidase in Escherichia coli.” ChemBioChem, 2011.
- H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, C.-H Lin, A.H.-J.Wang “Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range.” Angewandte Chemie-International Edition, 2010.
- Chiang BY, Chen TC, Pai CH, Chou CC, Chen HH, Ko TP, Hsu WH, Chang CY, Wu WF, Wang AH, Lin CH “Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION.” Journal of Biological Chemistry, 2010.
- Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin “Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells.” Proc. Natl. Acad. Sci. USA, 2009.
- D. B. Stein, Yu Nong. Lin, Chun Hung Lin* “Characterization of Helicobacter pylori α1,2-Fucosyltransferase for Enzymatic Syntehsis of Tumor-Associated Antigens.” Adv. Synth. Catal., 2008.
- H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin “Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.” J Biol Chem, 2007.
- C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin “Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase.” EMBO J, 2006.
- C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong and C. H. Lin “Discovery of Picomolar Slow Tight-Binding Inhibitors of alpha-Fucosidase.” Chemistry & Biology, 2004.
- C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin “Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.”Angewandte Chemie-International Edition, 2003.
更新日期: 2021-11-19