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Department of Chemistry


HSU, Cheng-Chih

HSU, Cheng-Chih
Associate Professor
Room B476, Chemistry Building
Fax: +886-2-3366-8671
Research Interest

  • Mass Spectrometry Imaging

  • Ambient Ionization Mass Spectrometry

  • Human Microbiota

  • Clinical Mass Spectrometry

Career and Service Experiences

  • 2001-2005 B.S., National Taiwan University.

  • 2005-2007 M.S., National Taiwan University.

  • 2008-2009 Research Assistant, National Taiwan University.

  • 2009-2014 Ph.D., University of California at San Diego (UCSD).

  • 2014-2015 Postdoctoral Research Associate, Stanford University.

  • 2015-2020, Assistant Professor, Department of Chemistry, National Taiwan University.

  • 2020-present, Associate Professor, Department of Chemistry, National Taiwan University.

Honors and Awards

  • 2015 Mass Spectrometry Imaging (MSI) Award

  • 2015 Outstanding Young Faculty Award

  • 2016 Recruiting Outstanding Young Scholar Award, FAOS

  • 2018 Top 40 Under 40 Power List 2018 of the Analytical Scientist

  • Future Tech Breakthrough Award 2018

  • Excellent Teaching Award 2018 of National Taiwan University

  • 2019 MOST Young Scholar Fellowship – Columbus Program

  • 2020 Excellent Teaching Award of National Taiwan University

  • 2020 Young Scholar Research Award of Taiwan Society for Mass Spectrometry

  • 2020 Outstanding Young Chemist Award, Chinese Chemical Society Located in Taipei

  • 2021 NHRI Career Development Grant (CDG)

Research Content
Selected Publications

  1. H.-H. Chung, C.-Y. Kao, T.-S. A. Wang, J. Chu, J.-Y. Pei,* C.‐C. Hsu,* “Reaction Tracking and High-throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking.” Anal. Chem. 2021, 93, 2456-2463. 

  2. C.-Y. Weng, T.-H. Kuo, L.M.X. Chai, H.-B. Zou, T.-H. Feng, Y.-J. Huang, J.C. Tsai, P.-H. Wu, Y.-W. Chiu, E. Lan, L.-Y. Sheen, C.-C. Hsu,* “Rapid Quantification of Gut Microbial Short-Chain Fatty Acids by pDART-MS.” Anal. Chem. 2020, 92, 14892-14897.

  3. P. Huang, C.-Y. Huang, T.-C. Lin, L.-E. Lin, E. Yang, C. Lee,* C.-C. Hsu,* P.-T. Chou,* “Towards the Rational Design of Universal Dual Polarity Matrix for MALDI Mass Spectrometry.” Anal. Chem. 2020, 92, 7139-7145.

  4. Y.-C. Huang, H.-H. Chung, E.P. Dutkiewicz, C.-L. Chen, H.-Y. Hsieh, B.-R. Chen, M.-Y. Wang,* C.-C. Hsu,* “Predicting Breast Cancer by Paper Spray Ion Mobility Spectrometry Mass Spectrometry and Machine Learning.” Anal. Chem. 2020, 92, 1653-1657. (featured as the Front Cover)

  5. L.-E. Lin, C.-L. Chen, Y.-C. Huang, H.-H. Chung, C.-W., Lin, K.-C. Chen, Y.-J. Peng, S.-T. Ding, M.-Y. Wang, T.-L. Shen, C.-C. Hsu,* “Precision Biomarker Discovery Powered by Microscopy Image Fusion-assisted High Spatial Resolution Ambient Ionization Mass Spectrometry Imaging.” Anal. Chim. Acta 2020, 1100, 75-87.

  6. T.-H. Kuo, H.-H. Chung, H.-Y. Chang, C.-W. Lin, M.-Y. Wang, T.-L.  Shen, C.-C. Hsu,* “Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation.” Anal. Chem. 2019, 91, 11905-11915.

  7. K.-H. Huang, T.-H. Tu, S.-C. Wang, Y.-T. Chan,* C.-C. Hsu,* “Micelles Protect Intact Metallo-supramolecular Block Copolymer Complexes from Solution to Gas Phase during Electrospray Ionization”, Anal. Chem. 2018, 90, 7691-7699.

  8. H.-Y. Hsieh, L.-H. Li, R.-Y. Hsu, W.-F. Kao, Y.-C. Huang, C.-C. Hsu,* “Quantification of Endogenous Cholesterol in Human Serum on Paper Using Direct Analysis in Real Time Mass Spectrometry.” Anal. Chem. 2017, 89, 6146-6152.   

  9. C.-C. Hsu, P.-T. Chou, R. N. Zare,* “Imaging of Proteins in Tissue Samples Using Nanospray Desorption Electrospray Ionization Mass Spectrometry.” Anal. Chem. 2015, 87, 11171-11175. 

  10. C.-C. Hsu, N. M. White, M. Hayashi, E. C. Lin, T. Poon, I. Banerjee, J. Chen, S. L. Pfaff, E. R. Macagno, P. C. Dorrestein,*“Microscopy Ambient Ionization Top-Down Mass Spectrometry Reveals Developmental Pattering.” Proc. Natl. Acad. Sci. USA. 2013, 110(37), 14855-14860.

  11. C.-C. Hsu, M. S. ElNaggar, Y. Peng, J. Fang, L. M. Sanchez, et al. “Real-Time Metabolomics on Living Microorganisms Using Ambient Electrospray Ionization Flow-Probe.” Anal. Chem. 2013, 85(15), 7014-7018.

Update: 2022-11-30