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國立臺灣大學化學系

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李弘文


李弘文
教授
化學館 A421室
電話: 02-3366-4089
傳真: 02-3366-8671
研究興趣
  • 單分子生物物理化學
  • DNA 同源重組機制
  • 蛋白質與DNA間的交互作用
  • 光學顯微鏡技術
簡歷

1993 年國立臺灣大學化學系學士;2000 年美國加州大學柏克萊校區化學博士;2000-2004 年美國 Brandeis 大學生化系博士後研究;2004-2007 年加拿大 McGill 大學化學系助理教授;2007-2014 年國立臺灣大學副教授;2014 年迄今國立臺灣大學教授;2018 年美國麻省理工學院生物系訪問教授

榮譽事項
  • 2000-2004 年Damon Runyon 癌症研究基金會博士後獎助
  • 2005-2007 年加拿大FQRNT優秀年輕學者
  • 2007-2012 年傑出人才發展基金會優秀年輕學者
  • 2010-2012 年臺灣大學教學優良獎
  • 2013 年臺灣大學教學傑出獎
研究內容
代表著作
  1. Lin, Y.-Y., Li, M.-H., Chang, Y.-C., Fu, P.-Y., Ohniwa, R. L., Li, H.-W.* & Lin, J.-J.*, “Dynamic DNA Shortening by Telomere-Binding Protein Cdc13” J. Am. Chem. Soc., 143, 5815-5825 (2021).
  2. Li, W.-C., Lee, C.-Y., Lan, W.-H., Woo, T.-T., Chen, C.-Y., Yeh, H.-Y., Chang, H.-Y., Liu, H.-C., Chen, C.-L., Chuang, C.-N., Hsueh, Y.-P., Li, H.-W.*, Chi, P.* & Wang, T.-F.*, “Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequences”Proc. Natl. Acad. Sci. U.S.A., 118, e2007192118 (2021).
  3. Luo, S.-C., Yeh, H.-Y., Lan, W.-H., Wu, Y.-M., Yang, C.-H., Chang, H.-Y., Su, G.-C., Lee, C.-Y., Wu, W.-J., Li, H.-W., Ho, M.-C.*, Chi, P.*& Tsai, M.-D.* “Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures” Nature Comm., 12, 115 (2021).
  4. Lan, W.-H., Lin, S.-Y., Kao, C.-Y., Chang, W.-H., Yeh, H.-Y., Chang, H.-Y., Chi, P.* & Li, H.-W.* "Rad51 Facilitates Filament Assembly of Meiosis-Specific Dmc1 Recombinase" Proc. Natl. Acad. Sci. U.S.A., 117, 11257-11264 (2020).
  5. Chang, H.-Y., Lee, C.-Y., Lu, C.-H., Lee, W., Hang, H.-L., Yeh, H.-Y., Li, H.-W.* & Chi, P.* "Microcephaly family protein MCPH1 stabilizes RAD51 filaments" Nucleic Acids Res., 48, 9135-9146 (2020).
  6. Tirtom, N.-S., Hsu, Y. & Li, H.-W.* "Polyamines Stimulate RecA-mediated Recombination by Condensing Duplex DNA and Stabilizing Intermediates" Phys. Chem. Chem. Phys., 22, 11928-11935 (2020).
  7. Lin, Y.-H., Chu, C.-C., Wang, P.-Y., Fan, H.-F. Cox, M. M.*, & Li, H.-W.*, “A 5'-to-3' Strand Exchange Polarity is Intrinsic to RecA Nucleoprotein Filaments in the Absence of ATP Hydrolysis”, Nucleic Acids Res., 47, 5126-40 (2019).
  8. Lu, C.-H., Yeh, H.-Y., Su, G.-C., Ito, K., Kurokawa, Y., Iwasaki, H.*, Chi, P.* & Li, H.-W.* “Swi5-Sfr1 Stimulates Rad51 Recombinase Filament Assembly by Modulating Rad51 Dissociation”, Proc. Natl. Acad. Sci. U.S.A., 115, E10059-68 (2018).
  9. Cho, C.-C., Chung, C. & Li, H.-W.* “How Chi Sequence Modifies RecBCD Single-Stranded DNA Translocase Activities”, ChemPhyChem, 19, 243-7 (2018).
  10. Lu, C.-H., Chang, T.-T., Cho, C.-C., Lin, H.-C. & Li, H.-W.* “Stable Nuclei of Nucleoprotein Filament and High ssDNA Binding Affinity Contribute to Enhanced RecA E38K Recombinase Activity”, Sci. Rep., 7, 14964 (2017).
  11. Wu, H.-Y., Lu, C.-H. & Li, H.-W.* “RecA-SSB Interaction Modulates RecA Nucleoprotein Filament Formation on SSB-Wrapped DNA”, Sci. Rep., 7, 11876 (2017).
  12. Lu, C.-H. & Li, H.-W.* “DNA with Different Local Torsional States Affects RecA-Mediated Recombination Progression”, ChemPhyChem, 18, 584-90 (2017).
  13. Li, J.-R., Yu, T.-Y., Chieh, I-.C., Lu, C.-Y., Lin, J.-J.* & Li, H.-W.*, “Pif1 Helicase Regulates Telomerase Activity by Removing from Telomere Ends”, Nucleic Acids Res., 42, 8527-8536 (2014).
  14. Chung, C. & Li, H.-W.*, “Direct Observation of RecBCD Helicase as Single-Stranded DNA Translocases” J. Am. Chem. Soc., 135, 8920-8925 (2013).
更新日期: 2021-04-28