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國立臺灣大學化學系

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朱忠瀚


朱忠瀚
助理教授
化學館 A521室
電話: 02-3366-8654
傳真: 02-3366-8671
實驗室
學術典藏
研究興趣

  • 非核糖體肽結構預測

  • 非核糖體肽化學合成

  • 天然物活性篩選

  • 抗菌、抗癌新藥開發

簡歷

  • 2004 年臺灣大學化學系學⼠

  • 2005-2011 美國史克利普斯研究所博⼠

  • 2011-2014 美國耶魯大學博⼠後研究

  • 2014-2019 美國洛克斐勒大學博⼠後研究

  • 2019 –迄今國立臺灣大學化學系助理教授

榮譽事項

  • 2019 國立臺灣大學化學系新進教師傑出研究獎助金

  • 2018 美國洛克斐勒大學 博士後協會職涯發展獎

  • 2013 美國耶魯大學 博士後學者旅行獎助金

  • 2011 美國德雷福斯 環境化學博士後獎學金

  • 2004 國立臺灣大學 陳安泰醫師研究獎學金

研究內容
代表著作

* Denotes equal contribution



  1. Wu, CH; Chu, J. Total synthesis and biological evaluation of pagoamide A. Front. Chem. 2021, 9: 741290.

  2. Chu, J; Koirala, B; Forelli, N; Vila-Farres, X; Ternei, MA; Ali, T; Colosimo, DA; Brady, SF. “Synthetic-bioinformatic natural product antibiotics with diverse modes of action.”  J. Am. Chem. Soc. 2020142, 14158

  3. Chu, J; Vila-Farres, X; Brady, SF. “Bioactive synthetic-bioinformatic natural product cyclic peptides inspired by nonribosomal peptide synthetase gene clusters from the human microbiome.”  J. Am. Chem. Soc. 2019141, 15737

  4. *Vila-Farres, X; *Chu, J; Ternei, MA; Lemetre, C; Park, S; Perlin, DS; Brady, SF “An optimized synthetic-bioinformatic natural product antibiotic sterilizes multidrug-resistant Acinetobacter baumannii-infected wounds.” mSphere 2018, 3, e00528-17.

  5. *Chu, J; *Vila-Farres, X; Inoyama, D; Gallardo-Macias, R; Jaskowski, M; Satish, S; Freudlich, JS; Brady, SF “Human microbiome inspired antibiotics with improved β-lactam synergy against MDR Staphylococcus aureus.” ACS Infect. Dis. 2018, 4, 33.

  6. Cohen, LJ; Esterhazy, D; Kim, SH; Lemetre, C; Aguilar, RR; Gordon, EA; Pickard, AJ; Cross, JR; Emiliano, AB; Han, SM; Chu, J; Vila-Farres, X; Kaplitt, J; Rogoz, A; Calle, P; Hunter, C; Bitok, JK; Brady, SF “Commensal bacteria make GPCR ligands that mimic human signaling molecules.” Nature 2017, 549, 48.

  7. *Vila-Farres, X; *Chu, J; Inoyama, D; Ternei, MA; Lemetre, C; Cohen, LJ; Cho, W; Reddy, BVB; Zebroski, HA; Freudlich, JS; Perlin, DS; Brady, SF “Antimicrobials inspired by nonribosomal peptide synthetase gene clusters.” J. Am. Chem. Soc. 2017, 139, 1404.

  8. *Chu, J; *Vila-Farres, X; Inoyama, D; Ternei, MA; Cohen, LJ; Gordon, EA; Reddy, BVB; Charlop-Powers, Z; Zebroski, HA; Gallardo-Macias, R; Jaskowski, M; Satish, S; Park S; Perlin, DS; Freudlich, JS; Brady, SF “Discovery of MRSA active antibiotics using primary sequence from the human microbiome.” Nat. Chem. Biol. 2016, 12, 1004.

更新日期: 2022-01-26